658704-24-6

Basic information

• Product Name: Benzenepropanol, 2-hydroxy-5-(methoxymethoxy)-
• CAS NO: 658704-24-6
• Molecular Formula: C11H16O4
• Molecular Weight: 212.246
• Mol File: 658704-24-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzenepropanol, 2-hydroxy-5-(methoxymethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanol, 2-hydroxy-5-(methoxymethoxy)-(658704-24-6)
• EPA Substance Registry System: Benzenepropanol, 2-hydroxy-5-(methoxymethoxy)-(658704-24-6)

Safety Data

• Hazardous Substances Data: 658704-24-6(Hazardous Substances Data)

Upstream product

• 476003-32-4 allyl 4-(methoxymethoxy)phenyl ether 
• 123-31-9 hydroquinone 
• 476003-33-5 2-(2-propenyl)-4-(methoxymethoxy)phenol 

Downstream Products

• 658704-26-8 2-(3-fluoropropyl)-4-(methoxymethoxy)-1-(trifluoromethanesulfonyloxy)benzene 
• 658704-25-7 2-(3-fluoropropyl)-1-hydroxy-4-(methoxymethoxy)benzene 

Relevant articles and documents

Synthesis and binding affinities of fluoroalkylated raloxifenes

Three fluoroalkylated derivatives (1-3) of the selective estrogen receptor modulator (SERM), raloxifene, have been synthesized. The key step in the synthesis is the C-C bond formation of benzo[b]thiophene and a substituted phenyl group (ring C) using a Stille reaction. The in vitro binding affinities of the substituted raloxifenes 1-3 are 45, 60, 89%, respectively, relative to the affinity of estradiol, which is higher than the affinity of raloxifene itself (25%). When labeled with the positron-emitting radionuclide, these compounds might be useful as PET imaging agents for estrogen receptor-positive breast tumors.