476003-32-4

Basic information

• Product Name: Benzene, 1-(methoxymethoxy)-4-(2-propenyloxy)-
• CAS NO: 476003-32-4
• Molecular Formula: C11H14O3
• Molecular Weight: 194.23
• Mol File: 476003-32-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(methoxymethoxy)-4-(2-propenyloxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(methoxymethoxy)-4-(2-propenyloxy)-(476003-32-4)
• EPA Substance Registry System: Benzene, 1-(methoxymethoxy)-4-(2-propenyloxy)-(476003-32-4)

Safety Data

• Hazardous Substances Data: 476003-32-4(Hazardous Substances Data)

Upstream product

• 123-31-9 hydroquinone 
• 6411-34-3 4-allyloxyphenol 
• 107-30-2 chloromethyl methyl ether 
• 57433-93-9 hydroquinone monomethoxymethyl ether 
• 106-95-6 allyl bromide 

Downstream Products

• 476003-50-6 acetic acid 2-benzenesulfonyl-1-[2-(6-methoxymethoxy-2-methyl-2H-chromen-2-yl)-ethyl]-2,6-dimethyl-hept-5-enyl ester 
• 476003-49-3 4-benzenesulfonyl-1-(6-methoxymethoxy-2-methyl-2H-chromen-2-yl)-4,8-dimethyl-non-7-en-3-ol 
• 476003-56-2 methyl (2E,4R,5R)-6-[2-(tert-butyldimethylsilyloxy)-5-(methoxymethoxy)phenyl]-4-methyl-4,5-epoxy-2-hexenoate 
• 476003-41-5 methyl (2E,4S,5S)-6-[2-(tert-butyldimethylsilyloxy)-5-(methoxymethoxy)phenyl]-4-methyl-4,5-epoxy-2-hexenoate 
• 476003-35-7 methyl (E)-4-[2-(tert-butyldimethylsilyloxy)-5-(methoxymethoxy)phenyl]-2-methyl-2-butenoate 
• 476003-55-1 (2R,3R)-4-[2-(tert-butyldimethylsilyloxy)-5-(methoxymethoxy)phenyl]-2-methyl-2,3-epoxy-butan-1-ol 
• 476003-37-9 (2S,3S)-4-[2-(tert-butyldimethylsilyloxy)-5-(methoxymethoxy)phenyl]-2-methyl-2,3-epoxy-butan-1-ol 
• 476003-36-8 (E)-4-[2-(tert-butyldimethylsilyloxy)-5-(methoxymethoxy)phenyl]-2-methyl-2-buten-1-ol 
• 476003-54-0 3-[2-(tert-butyldimethylsilyloxy)-5-(methoxymethoxy)phenyl]propane-1,2-diol 
• 476003-42-6 (E)-3-[(2S,3S)-3-(2-Hydroxy-5-methoxymethoxy-benzyl)-2-methyl-oxiranyl]-acrylic acid methyl ester 
• 476003-34-6 1-(tert-butyldimethylsilyloxy)-2-(2-propenyl)-4-(methoxymethoxy)benzene 
• 476003-33-5 2-(2-propenyl)-4-(methoxymethoxy)phenol 
• 658704-26-8 2-(3-fluoropropyl)-4-(methoxymethoxy)-1-(trifluoromethanesulfonyloxy)benzene 
• 658704-25-7 2-(3-fluoropropyl)-1-hydroxy-4-(methoxymethoxy)benzene 

Relevant articles and documents

Synthesis and binding affinities of fluoroalkylated raloxifenes

Three fluoroalkylated derivatives (1-3) of the selective estrogen receptor modulator (SERM), raloxifene, have been synthesized. The key step in the synthesis is the C-C bond formation of benzo[b]thiophene and a substituted phenyl group (ring C) using a Stille reaction. The in vitro binding affinities of the substituted raloxifenes 1-3 are 45, 60, 89%, respectively, relative to the affinity of estradiol, which is higher than the affinity of raloxifene itself (25%). When labeled with the positron-emitting radionuclide, these compounds might be useful as PET imaging agents for estrogen receptor-positive breast tumors.