658709-61-6Relevant academic research and scientific papers
Discovery, synthesis, and biological evaluation of thiazoloquin(az)olin(on)es as potent CD38 inhibitors
Haffner, Curt D.,Becherer, J. David,Boros, Eric E.,Cadilla, Rodolfo,Carpenter, Tiffany,Cowan, David,Deaton, David N.,Guo, Yu,Harrington, Wallace,Henke, Brad R.,Jeune, Michael R.,Kaldor, Istvan,Milliken, Naphtali,Petrov, Kim G.,Preugschat, Frank,Schulte, Christie,Shearer, Barry G.,Shearer, Todd,Smalley, Terrence L.,Stewart, Eugene L.,Stuart, J. Darren,Ulrich, John C.
, p. 3548 - 3571 (2015/05/05)
A series of thiazoloquin(az)olinones were synthesized and found to have potent inhibitory activity against CD38. Several of these compounds were also shown to have good pharmacokinetic properties and demonstrated the ability to elevate NAD levels in plasm
Novel coumarin-3-(N-aryl)carboxamides arrest breast cancer cell growth by inhibiting ErbB-2 and ERK1
Reddy, Natala Srinivasa,Gumireddy, Kiranmai,Mallireddigari, Muralidhar R.,Cosenza, Stephen C.,Venkatapuram, Padmavathi,Bell, Stanley C.,Reddy, E. Premkumar,Reddy, M.V. Ramana
, p. 3141 - 3147 (2007/10/03)
A series of novel coumarin carboxamides were synthesized, and their tumor cell cytotoxic activity was investigated. These compounds specifically inhibited the growth of cancer cells that have a high level of ErbB-2 expression. Immunoprecipitation analysis
6,6-FUSED HETEROARYL DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS
-
Page/Page column 229-230, (2008/06/13)
This invention provides compounds defined by Formula I or a pharmaceutically acceptable salt thereof, wherein Rl, Q, Yl, Y2, Y3, R 2a, 0, Rs, and n are as defined in the specification. The invention also provides pharmaceutical compositions comprising a c
