134430-72-1

Basic information

• Product Name: [18F]4'-fluorobenzyl iodide
• Synonyms: [18F]4'-fluorobenzyl iodide
• CAS NO: 134430-72-1
• Molecular Weight: 235.029
• Mol File: 134430-72-1.mol

Chemical Properties

• CAS DataBase Reference: [18F]4'-fluorobenzyl iodide(CAS DataBase Reference)
• NIST Chemistry Reference: [18F]4'-fluorobenzyl iodide(134430-72-1)
• EPA Substance Registry System: [18F]4'-fluorobenzyl iodide(134430-72-1)

Safety Data

• Hazardous Substances Data: 134430-72-1(Hazardous Substances Data)

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 659-46-1 4-[18F]fluorofluorobenzyl alcohol 
• 115109-21-2 4-[18F]fluorobenzaldehyde 

Downstream Products

• 62284-30-4 2-fluorobenzyl azide 
• 154824-77-8 (+)-[18F]fluorobenzyltrozamicol 

Relevant articles and documents

Esters of 6-(4'-Fluorobenzylamino)-β-carboline-3-carboxylic acid as potential benzodiazepine imaging agents for P.E.T.

As potential P.E.T. imaging agents for the benzodiazepine receptor, two fluorine-18 labeled analogues of the β-carbolines were prepared via N-alkylation of the corresponding desbenzyl amine precursors with [18F]fluorobenzyl iodide.

Fast and reliable method for the preparation of ortho- and para-[ 18F]fluorobenzyl halide derivatives: Key intermediates for the preparation of no-carrier-added PET aromatic radiopharmaceuticals

A fast and reliable method suitable for the automated preparation of (substituted) [18F]fluorobenzyl halides from several [ 18F]fluorobenzaldehydes was developed. Aromatic nucleophilic substitution of trimethylammonium benzaldehyde t

18F-labeled benzamides for studying the dopamine D2 receptor with positron emission tomography

Two series of (N-benzylpiperidin-4-yl)- and (9-azabicyclo[3.3.1]nonan- 3β-yl)benzamides were prepared, and in vitro binding assays were used to measure the affinity of these compounds for dopamine D2, dopamine D3, serotonin 5-HT2, and α2-adrenergic receptors. The results of these studies indicated compounds 23, 26b, and 34 have the selectivity needed for in vivo studies of the D2 (and possibly D3) receptors. 18F-Labeled analogues of 23, 26b and 34 were prepared by N-alkylation of the corresponding desbenzyl precursors with [18F]-4-fluorobenzyl iodide. Preliminary in vivo studies demonstrated that [18F]-23 and [18F]-26b are suitable candidates for further evaluation in positron emission tomography imaging studies. The slow rate of washout of [18F]-34 from nondopaminergic regions and its comparatively high lipophilicity indicates that this compound may not be suitable for imaging studies because of a high level of nonspecific binding.