65907-81-5

Basic information

• Product Name: 2,6-dimethyl-3,5-diphenylpyridine
• CAS NO: 65907-81-5
• Molecular Formula: C₁₉H₁₇N
• Molecular Weight: 259.345
• Mol File: 65907-81-5.mol

Chemical Properties

• Boiling Point: 364.4°C at 760 mmHg
• Flash Point: 154.2°C
• Density: 1.055g/cm³
• Vapor Pressure: 3.54E-05mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: 2,6-dimethyl-3,5-diphenylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-dimethyl-3,5-diphenylpyridine(65907-81-5)
• EPA Substance Registry System: 2,6-dimethyl-3,5-diphenylpyridine(65907-81-5)

Safety Data

• Hazardous Substances Data: 65907-81-5(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2,6-dimethyl-3,5-diphenylpyridine is utilized as a key intermediate in organic synthesis for the production of various complex organic molecules. Its unique structure allows for versatile chemical reactions, facilitating the synthesis of a wide range of compounds.
Used as a Ligand in Coordination Chemistry:
In coordination chemistry, 2,6-dimethyl-3,5-diphenylpyridine serves as a ligand, forming coordination complexes with metal ions. Its ability to chelate metals enhances the stability and properties of the resulting complexes, making it a useful component in the development of catalysts, sensors, and other functional materials.
Used in Pharmaceutical and Agrochemical Synthesis:
2,6-dimethyl-3,5-diphenylpyridine exhibits potential biological activity and is employed as a precursor in the synthesis of pharmaceuticals and agrochemicals. Its incorporation into these compounds can contribute to the development of new drugs and pesticides with improved efficacy and selectivity.
Used in Research and Development:
Due to its unique molecular structure and properties, 2,6-dimethyl-3,5-diphenylpyridine is a valuable compound for research and development in various fields, including chemistry, materials science, and biology. It can be used to explore new reaction mechanisms, investigate the properties of coordination complexes, and study the biological activity of related compounds.

Upstream product

• 98-80-6 phenylboronic acid 
• 633318-46-4 3,5-dibromo-4-chloro-2,6-dimethyl-pyridine 
• 593-51-1 methylamine hydrochloride 
• 103-79-7 1-phenyl-acetone 
• 40122-80-3 2,6-dimethyl-3-phenyl-4H-pyran-4-one 
• 915946-48-4 3-bromo-4-chloro-2,6-dimethyl-5-phenylpyridine 
• 137735-27-4 3-bromo-2,6-dimethyl-5-phenylpyridin-4(1H)-one 
• 3430-34-0 3,5-dibromo-2,6-dimethylpyridine 
• 915946-54-2 3-bromo-2,6-dimethyl-5-phenylpyridine 
• 138642-48-5 2,6-dimethyl-3-phenylpyridin-4(1H)-one 

Relevant articles and documents

Atropisomerism in 3,4,5-Tri-(2-methoxyphenyl)-2,6-lutidine

Suzuki reaction of tribromo-2,6-lutidine with (2-methoxyphenyl)boronic acid gave 3,4,5-tris(2-methoxyphenyl)-2,6-lutidine in the form of a mixture of three atropisomers that were stable at room temperature. Each isomer was isolated and fully characterized

Characterization of route specific impurities found in methamphetamine synthesized by the Leuckart and reductive amination methods

Impurity profiling of seized methamphetamine can provide very useful information in criminal investigations and, specifically, on drug trafficking routes, sources of supply, and relationships between seizures. Particularly important is the identification of "route specific" impurities or those which indicate the synthetic method used for manufacture in illicit laboratories. Previous researchers have suggested impurities which are characteristic of the Leuckart and reductive amination (Al/Hg) methods of preparation. However, to date and importantly, these two synthetic methods have not been compared in a single study utilizing methamphetamine hydrochloride synthesized in-house and, therefore, of known synthetic origin. Using the same starting material, 1-phenyl-2-propanone (P2P), 40 batches of methamphetamine hydrochloride were synthesized by the Leuckart and reductive amination methods (20 batches per method). Both basic and acidic impurities were extracted separately and analyzed by GC/MS. From this controlled study, two route specific impurities for the Leuckart method and one route specific impurity for the reductive amination method are reported. The intra- and inter-batch variation of these route specific impurities was assessed. Also, the variation of the "target impurities" recently recommended for methamphetamine profiling is discussed in relation to their variation within and between production batches synthesized using the Leuckart and reductive amination routes.

A Suzuki-Miyaura approach to a series of forensically relevant pyridines

A convenient and general method for the preparation of sixteen 3,5-diarylsubstituted 2,4- and 2,6-dimethylpyridines of high forensic importance is described. The Suzuki cross-coupling reaction between a range of ring-substituted phenylboronic acids and 3,