65911-47-9

Upstream product

• 85-44-9 phthalic anhydride 
• 610-27-5 4-nitrophthalic acid 
• 5466-84-2 4-nitrophthalic anhydride 
• 57-13-6 urea 

Downstream Products

• 1314437-54-1 C₁₂H₁₇Cl₂N₄O₅P 
• 1314437-79-0 C₈H₈N₂O₄ 
• 153702-68-2 3-(4-methoxyphenyl)-7-nitroquinazoline-4-one 
• 619-17-0 4-Nitroanthranilic acid 

Relevant academic research and scientific papers

Phthalimidomethyl as a drug pro-moiety. Probing its reactivity

Phthalimidomethyl derivatives 1, encompassing a wide range of leaving group abilities, are rapidly hydrolysed to the corresponding phthalamic acid via rate-determining attack at the phthalimide carbonyl group.

Synthesis method of 2,4-diaminobenzoic acid

The present invention discloses a synthesis method of 2,4-diaminobenzoic acid, and belongs to the field of chemical synthesis. The synthesis method comprises the following steps: using phthalic anhydride as a raw material; adding concentrated sulfuric acid and fuming nitric acid to generate 4-nitrophthalic acid; adding acetic anhydride into the 4-nitrophthalic acid and heating until the solid is completely dissolved; washing ether to obtain 4-nitro phthalic anhydride; mixing and heating the 4-nitro phthalic anhydride with urea; evacuating a reaction system; then adding hydrochloric acid to obtain 4-nitro-2-formyl acetaminobenzoic acid; obtaining 2-amino-4-nitrobenzoic acid under the conditions of a sodium hypochlorite solution and an ice bath; and finally refluxing with absolute ethanol, and adding an ammonium sulfide solution to finally produce 2,4-diaminobenzoic acid by using microwave heating and other conditions.