153702-68-2Relevant academic research and scientific papers
DESIGN OF ANTINEOPLASTIC AGENTS ON THE BASIS OF THE "2-PHENYLNAPHTHALENE-TYPE" STRUCTURAL PATTERN.I. SYHTHESIS OF SUBSTITUTED 3-PHENYLQUINAZOLONES, BENZOXAZOLOQUINAZOLONES AND BENZOTHIAZOLOQUINAZOLONES
Cheng, Chia-Chung,Liu, Den-Fu,Chou, Ting-Chao
, p. 775 - 789 (1993)
A number of substituted 3-phenylquinazolin-4-ones, 12H-benzoxazoloquinazolin-12-ones and 12H-benzothiazoloquinazolin-12-ones were designed and synthesized on the basis of a "2-phenylnaphthalene-type" structural pattern hypothesis.The posulated pattern, which was uncovered among a substantial number of compounds of both natural and synthetic origins, was noted to be associated with compounds possessing a variety of biological properties which include the antineoplastic activity.Several compounds designed for the present study were found to exhibit potentcytotoxicity against the growth of human promyelocytic leukemia (HL-60)cells.
