65912-40-5Relevant academic research and scientific papers
The photomediated reaction of alkynes with cycloalkanes
Doohan, Roisin A.,Hannan, John J.,Geraghty, Niall W.A.
, p. 942 - 952 (2006)
In the presence of a photomediator such as benzophenone, alkynes with electron-withdrawing groups react with cycloalkanes to give vinyl cycloalkanes. The reaction involves the regiospecific addition of a photochemically generated cycloalkyl radical to the β-carbon of the alkyne. The stereochemical outcome of the reaction depends on the nature of the photomediator and alkyne used. The Royal Society of Chemistry 2006.
Chemistry and structure-activity relationships of C-17 unsaturated 18-cycloalkyl and cycloalkyl analogues of enisoprost. Identification of a promising new antiulcer prostaglandin
Collins,Gasiecki,Perkins,Gullikson,Bianchi,Kramer,Ng,Yonan,Swenton,Jones,Bauer
, p. 2784 - 2793 (2007/10/02)
A series of Δ17 unsaturated cycloalkyl and cycloalkenyl analogues of enisoprost was synthetized to investigate the effects of ω chain unsaturation on gastric antisecretory activity and diarrheogenic side effects. Of these, the 17E, 18-cyclopent
Cobalt-Mediated Intermolecular Radical Additions to Carbon-to-Carbon Double Bonds leading to New Functionalised Alkenes
Bhandal, Harcharan,Howell, Amy R.,Patel, Vinod F.,Pattenden, Gerald
, p. 2709 - 2714 (2007/10/02)
Alkyl radicals generated by photolytic homolysis of cobalt salophen reagents, e.g. (6) and (15), are shown to add to activated carbon-to-carbon double bonds, i.e. ethyl acrylate, methyl vinyl ketone, acrylonitrile, and styrene, producing preparatively useful yields of new alkene products, viz. (9), (10), (12) and (14) , and (16) .The reactions proceed via radical (Michael) additions, followed by 'dehydrocobaltation' from the presumed organocobalt intermediates (2) (Scheme 4).By use of this chemistry, in combination with the Schrauzer 'hydrocobaltation' reaction of alkenes, a new method for the cross-coupling reactions between two alkenes, leading to new functionalised alkenes, e.g. (24), (25), (26), (27), (28), and (29), is developed .
Cobalt Mediated Radical Addition-Elimination Carbon-Carbon Bond Forming Reactions in Synthesis
Patel, Vinod F.,Pattenden, Gerald
, p. 871 - 872 (2007/10/02)
Alkyl radicals generated by photolytic homolysis of cobalt 'salophen' reagents add to activated carbon-carbon double bonds producing preparatively useful yields of new alkene products; the reactions proceed via radical (Michael) addition, followed by elimination of H-Co.
