131391-99-6

Basic information

• Product Name: 3-(2,4-dihydroxyphenyl) coumarin
• Synonyms: 3-(2,4-dihydroxyphenyl) coumarin
• CAS NO: 131391-99-6
• Molecular Weight: 254.242
• Mol File: 131391-99-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-(2,4-dihydroxyphenyl) coumarin(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2,4-dihydroxyphenyl) coumarin(131391-99-6)
• EPA Substance Registry System: 3-(2,4-dihydroxyphenyl) coumarin(131391-99-6)

Safety Data

• Hazardous Substances Data: 131391-99-6(Hazardous Substances Data)

Upstream product

• 131391-98-5 ethyl 2-methoxy-(α-2,4-dimethoxyphenyl)cinnamate 
• 17715-69-4 1-Bromo-2,4-dimethoxybenzene 
• 6592-19-4 (2,4-dimethoxyphenyl)-glyoxalic acid ethyl ester 
• 52045-25-7 (2-methoxyphenylmethyl)triphenylphosphonium chloride 
• 90-02-8 salicylaldehyde 
• 614-82-4 (2,4-dihydroxyphenyl)acetic acid 
• 100-52-7 benzaldehyde 

Relevant articles and documents

Synthesis of Phenolic Coumestans via a Sequential Dehydrogenation/Oxa-Michael Addition Reaction of 2′,4′-Dihydroxyl-3-arylcoumarins

A facile and practical approach for the synthesis of natural coumestans and derivatives starting from 2′,4′-dihydroxyl-3-arylcoumarins has been developed. The process involved a seqential intramolecular dehydrogenation/oxa-Micheal reaction efficiently promoted by 1,8-diazabicyclo[5.4.0]undec-7-ene at 40 °C under metal- and ligand-free conditions with good functional group compatibility.

Useful Synthesis of Coumestans

A convenient synthesis of coumestans involving a combination of lithiation and Wittig reactions is described.Compounds 1a and 1b on reaction with n-butyllithium followed by treatment with diethyloxalate provide ketoesters 3a and 3b.Reaction of 3(a-b) with