65935-05-9Relevant academic research and scientific papers
Unprecedented "in water" imidazole carbonylation: Paradigm shift for preparation of urea and carbamate
Padiya, Kamlesh J.,Gavade, Sandip,Kardile, Bhavana,Tiwari, Manojkumar,Bajare, Swapnil,Mane, Madhav,Gaware, Vivek,Varghese, Shaji,Harel, Dipak,Kurhade, Suresh
supporting information; experimental part, p. 2814 - 2817 (2012/08/07)
The first "In Water" imidazolecarbonylation of amine is described. A one pot reaction of carbonylimidazolide in water with a nucleophile provides an efficient and general method for the preparation of urea, carbamates and thiocarbamates. Use of an anhydrous solvent and an inert atmosphere could be avoided. Product precipitate out from the reaction mixture and can be obtained in high purity by filtration, resulting in a simple and scalable method.
Synthesis and anti-trypanosomal activity of novel 5-nitro-2-furaldehyde and 5-nitrothiophene-2-carboxaldehyde semicarbazone derivatives
Cerecetto, Hugo,Di Maio, Rossanna,Ibarruri, Gerardo,Seoane, Gustavo,Denicola, Ana,Peluffo, Gonzalo,Quijano, Celia,Paulino, Margot
, p. 89 - 94 (2007/10/03)
Several novel semicarbazones derivatives were prepared from 5-nitro-2-furaldehyde or 5-nitrothiophene-2-carboxaldehyde, and tested in vitro as potential anti-trypanosomal agents. The compounds were prepared in good to excellent yields in 2-3 steps from readily available starting materials. Some derivatives were found to be active against Trypanosoma cruzi with an activity similar to that of Nifurtimox.
