65940-16-1

Upstream product

• 1738-76-7 glycine benzyl ester p-toluenesulfonic acid salt 
• 100-52-7 benzaldehyde 
• 100-46-9 benzylamine 
• 5437-45-6 Benzyl bromoacetate 
• 52267-51-3 benzyl diazoacetate 

Downstream Products

• 110353-55-4 benzyl 2-[(N-benzyl-N-benzyloxicarbonyl)amino]acetate 
• 110353-56-5 benzyl N-benzyl-N-(methoxycarbonyl)glycinate 
• 110353-58-7 benzyl N-benzyl-N-<(2,2,2-trichloroethoxy)carbonyl>glycinate 
• 388604-54-4 benzyl N-(bis(benzyloxymethyl)phosphoryl)methyl-N-benzylglycinate 
• 1202789-04-5 2-benzyl-3-(2,2-dimethyl-3a,6a-dihydro-furo[2,3-d][1,3]dioxol-5-yl)-4,6-dioxo-5-phenyl-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid benzyl ester 
• 1202789-07-8 2-benzyl-3-(2,2-dimethyl-3a,6a-dihydro-furo[2,3-d][1,3]dioxol-5-yl)-4,6-dioxo-5-phenyl-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid benzyl ester 
• 1202789-02-3 2-benzyl-3-(2,2-dimethyl-3a,6a-dihydro-furo[2,3-d][1,3]dioxol-5-yl)-4,6-dioxo-5-phenyl-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid benzyl ester 
• 1202789-09-0 2-benzyl-3-(2,2-dimethyl-3a,6a-dihydro-furo[2,3-d][1,3]dioxol-5-yl)-4,6-dioxo-5-phenyl-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid benzyl ester 
• 1202789-11-4 2-benzyl-3-(2,2-dimethyl-3a,6a-dihydro-furo[2,3-d][1,3]dioxol-5-yl)-4,6-dioxo-5-p-tolyl-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid benzyl ester 
• 1202789-17-0 2-benzyl-3-(2,2-dimethyl-3a,6a-dihydro-furo[2,3-d][1,3]dioxol-5-yl)-4,6-dioxo-5-p-tolyl-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid benzyl ester 
• 1202789-13-6 2-benzyl-3-(2,2-dimethyl-3a,6a-dihydro-furo[2,3-d][1,3]dioxol-5-yl)-4,6-dioxo-5-p-tolyl-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid benzyl ester 
• 1202789-15-8 2-benzyl-3-(2,2-dimethyl-3a,6a-dihydro-furo[2,3-d][1,3]dioxol-5-yl)-4,6-dioxo-5-p-tolyl-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid benzyl ester 
• 110353-57-6 benzyl N-benzyl-N-<(tert-butoxy)carbonyl>glycinate 

Relevant academic research and scientific papers

Selective Functionalization of Aliphatic Amines via Myoglobin-Catalyzed Carbene N-H Insertion

Engineered myoglobins have recently gained attention for their ability to catalyze a variety of abiological carbene transfer reactions including the functionalization of amines via carbene insertion into N-H bonds. However, the scope of myoglobin and other hemoprotein-based biocatalysts in the context of this transformation has been largely limited to aniline derivatives as the amine substrates and ethyl diazoacetate as the carbene donor reagent. In this report, we describe the development of an engineered myoglobin-based catalyst that is useful for promoting carbene N-H insertion reactions across a broad range of substituted benzylamines and α-diazo acetates with high efficiency (82-99percent conversion), elevated catalytic turnovers (up to 7,000), and excellent chemoselectivity for the desired single insertion product (up to 99percent). The scope of this transformation could be extended to cyclic aliphatic amines. These studies expand the biocatalytic toolbox available for the selective formation of C-N bonds, which are ubiquitous in many natural and synthetic bioactive compounds.

HETEROCYCLIC SULFONAMIDE DERIVATIVE AND MEDICINE COMPRISING SAME

The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a pharmaceutically acceptable salt thereof. The compound has a superior TRPA1 antagonist activity, and can provide a medicament useful for the prophylaxis or treatment of diseases involving TRPA1 antagonist and TRPA1.

Diastereoselective synthesis of pyrrolidines via 1,3-dipolar cycloaddition of a chiral azomethine ylide

1,3-Dipolar cycloaddition of d-glucose-derived azomethine ylides for the synthesis of chiral pyrrolidines accompanied an unexpected 1,2-elimination in the furanose moiety of the products. The C3′ alkoxy/hydroxy group of the furanose moiety was invariably eliminated under the reaction conditions. Also, in contrast to the previous reports, moderate to good exo-diastereoselectivity was observed in the reaction products.