6595-49-9

Basic information

• Product Name: 1H-Benzimidazole,1-methyl-2-(1-methylethoxy)-(9CI)
• Synonyms: 1H-Benzimidazole,1-methyl-2-(1-methylethoxy)-(9CI)
• CAS NO: 6595-49-9
• Molecular Formula: C11H14N2O
• Molecular Weight: 190.24166
• Product Categories: BENZIMIDAZOLE
• Mol File: 6595-49-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 290.9±23.0 °C(Predicted)
• Appearance: /
• Density: 1.10±0.1 g/cm3(Predicted)
• PKA: 6.29±0.10(Predicted)
• CAS DataBase Reference: 1H-Benzimidazole,1-methyl-2-(1-methylethoxy)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole,1-methyl-2-(1-methylethoxy)-(9CI)(6595-49-9)
• EPA Substance Registry System: 1H-Benzimidazole,1-methyl-2-(1-methylethoxy)-(9CI)(6595-49-9)

Safety Data

• Hazardous Substances Data: 6595-49-9(Hazardous Substances Data)

Upstream product

• 1849-02-1 2-chloro-1-methyl-benzimidazole 
• 67-63-0 isopropyl alcohol 

Relevant articles and documents

Cs2CO3-Promoted C?O Coupling Protocol Enables Solventless (Hetero)aryl Ether Synthesis under Air Atmosphere

In this work, a Cs2CO3-promoted synthetic approach was identified for (hetero)aryl ether synthesis via the C?O coupling of various (hetero)aryl chlorides and alcohols/phenol. To our delight, the reactions could be carried out under transition-metal-free and solvent-free conditions. Moreover, analytical-grade reagents and air atmosphere were readily tolerated. To showcase the practical usefulness of the present protocol, the assembly of a bioactive molecule was facilely realized and the gram-scale production of selected ether products was also efficiently accomplished. In addition, density functional theory (DFT) studies, along with a few mechanistic experiments, were conducted to elucidate a proposed reaction pathway and rationalize the pivotal role of Cs2CO3 in promoting this process. Hopefully, this work could provide useful information for researchers who are engaging in C?O cross-coupling reactions.