659723-53-2

Upstream product

• 150192-39-5 2-Bromo-5-methoxybenzyl alcohol 
• 7507-86-0 2-bromo-5-methoxy-benzaldehyde 
• 1530-32-1 ethyltriphenylphosphonium bromide 
• 6971-51-3 3-methoxybenzyl alcohol 
• 591-31-1 3-methoxy-benzaldehyde 
• 293731-09-6 1-bromo-4-methoxy-2-(prop-1-en-1-yl)benzene 

Downstream Products

• 1351765-52-0 (E)-4-methoxy-N-phenyl-2-(prop-1-enyl)benzamide 
• 1351766-00-1 6-methoxy-3-methyl-2-phenylisoquinolin-1(2H)-one 
• 1351765-98-4 5-methoxy-2-phenyl-3-vinylisoindolin-1-one 
• 1351765-37-1 (E)-4-methoxy-2-(prop-1-enyl)benzoic acid 

Relevant academic research and scientific papers

Enantioselective synthesis of 1-aminoindene derivativesviaasymmetric Br?nsted acid catalysis

We describe a catalytic asymmetric iminium ion cyclization reaction of simple 2-alkenylbenzaldimines using a BINOL-derived chiralN-triflyl phosphoramide. The corresponding 1-aminoindenes and tetracyclic 1-aminoindanes are formed in good yields and high enantioselectivities. Further, the chemical utility of the obtained enantiopure 1-aminoindene is demonstrated for the asymmetric synthesis of (S)-rasagiline.

Intriguing substituent effect in modified Hoveyda-Grubbs metathesis catalysts incorporating a chelating iodo-benzylidene ligand

A series of modified Hoveyda-Grubbs catalysts incorporating a chelating iodo-benzylidene ligand were prepared and characterized. The presence of electron-withdrawing ring substituents in the para position to the iodide was found to decrease the catalytic activity, revealing that dissociation of the Ru...I-Ar bond is not the rate-determining step.

Studies on the intramolecular oxa-Pictet-Spengler rearrangement of 5-aryl-1,3-dioxolanes to 4-hydroxy-isochromans

The success and stereochemical outcome of the TiCl4-promoted oxa-Pictet-Spengler cyclization of 5-aryl-1,3-dioxolanes to produce 1,3-disubstituted-4-hydroxy-isochromans, is influenced by the length and nature of the side chains bound to C-2 and C-4 of the dioxolane. Methyl groups yield a mixture of 4-hydroxy-isochromans in which the 1,3-trans diastereomer predominates, while bulkier substituents give 1,3-cis diastereomers. Functional groups in the C-2 side chain of the dioxolane ring may hinder cyclization by complexation with the promoter.

Model Studies Towards Stephaoxocanes: Construction of the 2-Oxa-4-azaphenalene Core of Stephaoxocanidine and Eletefine

The construction of the polysubstituted 1H,3H-2-oxa-4-azaphenalene 4 by means of consecutive oxa-Pictet-Spengler and Jackson cyclizations is reported. This compound contains the ABC ring system of the novel isoquinoline alkaloids stephaoxocanidine and ele