659737-57-2

Usage

Uses

Used in Research and Development:
1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy(9CI) is used as a reactant or synthetic intermediate for the development of various products. Its unique molecular structure and reactivity make it a valuable component in the synthesis of complex organic compounds and pharmaceuticals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy(9CI) is used as a key building block in the synthesis of potential drug candidates. Its presence in the molecular structure can contribute to the desired biological activity and therapeutic effects of the final drug product.
Used in Chemical Synthesis:
1H-Isoindol-1-one, 2,3-dihydro-6-hydroxy(9CI) is employed as a synthetic intermediate in the chemical synthesis of various compounds. Its versatility in forming different chemical bonds and its compatibility with a range of reaction conditions make it a useful component in the creation of new chemical entities.

Upstream product

• 73502-03-1 methyl 5-methoxy-2-methyl-benzoate 
• 788081-99-2 methyl 2-(bromomethyl)-5-methoxy-benzoate 
• 22246-66-8 6-methoxy-2,3-dihydro-isoindol-1-one 

Relevant academic research and scientific papers

Synthesis and structure-activity relationship of novel lactam-fused chroman derivatives having dual affinity at the 5-HT1A receptor and the serotonin transporter

The structure-activity relationship (SAR) for three series of lactam-fused chroman derivatives possessing 3-amino substituents was evaluated. Many compounds exhibited affinities for both the 5-HT1A receptor and the 5-HT transporter. Compounds 45 and 53 demonstrated 5-HT1A antagonist activities in the in vitro cAMP turnover model.

Synthesis of methyl-, fluoro-, and chloro-substituted 6-hydroxyisoindolin-1-ones

The synthesis of a series of methyl-, fluoro-, and chloro-substituted 6-hydroxyisoindolin-1-ones is described.

HETEROCYCLIC AMIDE COMPOUNDS AS PROTEIN KINASE INHIBITORS

The present invention related to novel heterocyclic amide compounds of Formula 1: as disclosed herein or a pharmaceutically accept able salt, solvate, ester, prodrug or stereoisomer thereof. Also disclosedare compositions comprising said compounds, and methods for using said compounds for treating or preventing a proliferative disease, an anti-proliferative disorder, inflammation, arthritis, a neurological or neurodenerative disease, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease or a fungal disease

ISOINDOLE DERIVATIVES

This invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, a process of making these compounds, pharmaceutical compositions containing one or more of these compounds or their salts, and their use for the treatment of schizophrenia, bipolar disorder, or other central nervous system disorders.

TRICYCLIC COMPOUNDS USEFUL AS SEROTONIN INHIBITORS AND 5-HT1A AGONISTS AND ANTAGONISTS

3-Amino chroman and 2-amino tetralin derivatives and compositions containing such compounds are disclosed. Such compounds are useful for modulating activity of a 5-HT1A receptor (agonizing or antagonizing) in a patient. These compounds are further useful for inhibiting binding to a serotonin receptor. Methods of using the 3-amino chroman and 2-amino tetralin compounds and compositions containing such compounds in the treatment of serotonin disorders, such as depression and anxiety, are also disclosed.

2,3-DIHYDRO-ISOINDOL-1-ONES WITH MAO-B INHIBITING ACTIVITY

2,3 Dihydro-isoindol-1-one derivatives, processes for their production, their use as pharmaceuticals and pharmaceutical compositions comprising them, for the prevention and treatment of diseases which are mediated by monoamine oxidase B inhibitors.