659746-56-2Relevant academic research and scientific papers
A Facile Synthesis of AICAR from Inosine
Kohyama, Naoki,Yamamoto, Yukio
, p. 2639 - 2642 (2007/10/03)
5-Amino-1-β-D-ribofuranosylimidazole-4-carboxamide (AICAR; 1) (Figure 1) was efficiently prepared from inosine through its 1-alkoxymethylderivatives. The stability of these derivatives enabled their purification by column chromatography (silica gel). The operation ensured the high quality of 1, which was obtained in good yield through alkaline hydrolysis of the derivatives.
