659747-10-1Relevant academic research and scientific papers
Visible-Light Photoredox Synthesis of Chiral α-Selenoamino Acids
Jiang, Min,Yang, Haijun,Fu, Hua
supporting information, p. 1968 - 1971 (2016/06/01)
N-Acetoxyphthalimide derivatives of two genetically coded proteinogenic amino acids, l-aspartic acid and glutamic acid, were used as visible light photoredox chiral sources and radical precursors, diorganyl diselenides were used as the radical acceptors,
An Efficient Synthesis of a Probe for Protein Function: 2,3-Diaminopropionic Acid with Orthogonal Protecting Groups
Englund, Ethan A.,Gopi, Hosahudya N.,Appella, Daniel H.
, p. 213 - 215 (2007/10/03)
(Matrix presented) An efficient and cost-effective synthesis of N(α)-Boc2-N(β)-Cbz-2,3-diaminopropionic acid is reported. The synthesis starts from commercially available N(α)-Boc-Asp(OBn)-OH and employs a Curtius rearrangement to establish the β-nitrogen. Proper protection of the α-nitrogen is essential for the success of the Curtius rearrangement.
A new synthesis of cyclotheonamide B via guanidination of ornithine
Deng, Jingen,Hamada, Yasumasa,Shioiri, Takayuki
, p. 2261 - 2264 (2007/10/03)
A macrocyclic thrombin inhibitor, cyclotheonamide B (1, R = Ac) was synthesized via a new approach: guanidination of the ornithine-containing macrocyclic peptide (2). In comparison of various coupling reagents, pentafluorophenyl diphenylphosphinate (FDPP) gave the macrocyclic peptide (2) in good yield, and the configuration of the amino acid residue has been revealed to be important for the macrolactamization.
