65983-36-0

Usage

Uses

Used in Pharmaceutical Research:
Methyl (R)-thiazolidine-4-carboxylate hydrochloride is used as a chiral building block for the synthesis of various pharmaceuticals and bioactive compounds. Its unique structure and properties make it a valuable component in the development of new drugs and materials.
Used in Organic Synthesis:
In the field of organic synthesis, methyl (R)-thiazolidine-4-carboxylate hydrochloride is used as a reagent to facilitate the creation of complex organic molecules. Its versatility and reactivity contribute to its utility in this application.
Used in Drug Development:
Methyl (R)-thiazolidine-4-carboxylate hydrochloride may have applications in the development of new drugs, given its potential as a chiral building block. Its role in the synthesis of pharmaceuticals could lead to the discovery of novel therapeutic agents.

InChI:InChI=1/C5H9NO2S.ClH/c1-8-5(7)4-2-9-3-6-4;/h4,6H,2-3H2,1H3;1H/t4-;/m0./s1

Upstream product

• 67-56-1 methanol 
• 34592-47-7 L-thioproline 

Downstream Products

• 1065331-94-3 (R)-3-(3-(2-(5-methyl-2-(4-trifluoromethylphenyl)oxazol-4-yl)ethoxy)benzyl)thiazolidine-4-carboxylic acid methyl ester 
• 126110-79-0 (R)-3-[(S)-2-[Hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-6-(2,2,2-trifluoro-acetylamino)-hexanoyl]-thiazolidine-4-carboxylic acid methyl ester 
• 1239587-90-6 C₂₀H₂₀N₂O₇S 

Relevant academic research and scientific papers

New thioureas based on thiazolidines with antioxidant potential

Thiazolidine and pyrrolidine compounds containing a thiourea moiety were prepared using boric acid as a coupling agent in a multicomponent methodology. In addition, the antioxidant activity, as reflected by free radical scavenging, was evaluated. Some compounds were selected and tested in different antioxidant experiments and all of them were shown to be useful for the prevention of oxidative stress in biological systems and thus capable of reducing cellular injury.

Asymmetric Michael reaction promoted by chiral thiazolidine-thiourea catalyst

In this work, we report the synthesis and characterization of three new thiazolidine- and thiourea-based chiral organocatalysts. These compounds were successfully applied in asymmetric Michael addition reactions between different ketones and nitrostyrenes leading to products in up to 85% yield, >96:4 r.d. and 97% e.e. Computational studies were used to better visualize the proposed transition state and explain the observed stereoselectivities. One of the new catalysts was also successfully applied in an aldol addition between cyclohexanone an p-nitrobenzaldehyde leading to product in 80% yield, >96:4 d.r. and 80% e.e.

NOVEL BENZODIAZEPINE DERIVATIVES

The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and (II), in which the diazepine ring (B) is fused with a heterocyclic ring (CD), wherein the heterocyclic ring is bicyclic or a compound of formula (III), in which the diazepine ring (B) is fused with a heterocyclic ring (C), wherein the heterocyclic ring is monocyclic. The invention provides cytotoxic dimers of these compounds. The invention also provides conjugates of the monomers and the dimers. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. The invention further relates to methods of using the compounds or conjugates for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.