6599-85-5Relevant academic research and scientific papers
Bifunctional pyridoxal derivatives as efficient bioorthogonal reagents for biomacromolecule modifications
Duan, Yuting,Fei, Jiayue,Li, Wei,Mao, Xianxian,Tian, Hongyan,Wang, Xiaojian,Wang, Yuntao,Zhu, Shiyu,Zou, Juan
supporting information, p. 7601 - 7604 (2020/08/25)
Two types of pyridoxal analogs, azido pyridoxal (PL-N3) and carboxyl pyridoxal (PL-COOH), were developed as novel bifunctional bioorthogonal molecules. These molecules showed fast imine formation with hydrazinyl groups and stable covalent linkages via azido/carboxyl groups, and thus were of great use for site-specific peptide and protein modifications.
