66000-38-2Relevant academic research and scientific papers
Photocontrol of ion permeation in lipid vesicles with (bola)amphiphilic spirooxazines
Kandasamy, Yamuna S.,Cai, Jianxin,Ottaviano, John G.,Smith, Kelti A.,Williams, Ashley N.,Moore, Jarod,Louis, Kristen M.,Selzler, Lindsay,Beler, Alisha,Okwuonu, Tobechi,Murphy, R. Scott
, p. 296 - 308 (2015)
Three (bola)amphiphilic spirooxazines have been synthesized and their photochromism has been characterized. The large biphotochromic structure of 2 significantly affects its conformational flexibility and the rate constants for thermal ring closure are particularly dependent on the lipid phase state. Two comprehensive ion permeation studies were performed to examine the effect of spirooxazine inclusion and isomerization on membrane permeability. In all cases, the open-ring isomers of these spirooxazines are more disruptive in bilayer membranes than their closed-ring isomers. Further, the rate of ion permeation and net release are highly dependent on the lipid bilayer phase state and the relative position of the photochromic moiety in the bilayer membrane. Moreover, the difference in potassium ion permeability under UV and visible irradiation is more pronounced than previously reported photoresponsive membrane disruptors with reversible photocontrols.
Copper(I)/Copper(II)-Assisted Tandem Catalysis: The Case Study of Ullmann/Chan-Evans-Lam N1,N3-Diarylation of 3-Aminopyrazole
Beyer, Astrid,Castanheiro, Thomas,Busca, Patricia,Prestat, Guillaume
, p. 2433 - 2436 (2015/08/24)
Unprecedented CuI/CuII-assisted tandem catalysis allowing an Ullmann/Chan-Evans-Lam sequence was achieved. This three-component, one-pot reaction triggered by a change in the oxidation state of the metal leads to the selective N1,N3-diarylation of 3-aminopyrazole. This new method should be a valuable tool for small-molecule drug discovery that requires suitable regio- and/or chemoselective strategies for the N-arylation of nitrogen-containing heterocycles. Tandem power: The first assisted tandem copper-catalyzed process, triggered by a change in the oxidation state of the metal, is developed to allow a one-pot Ullman/Chan-Evans-Lam sequence leading to the selective N1,N3-diarylation of 3-aminopyrazole.
Process for preparing 1-phenyl-3-aminopyrazoles
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, (2008/06/13)
1-PHENYL-3-AMINO-2-PYRAZOLINES ARE CATALYTICALLY OXIDIZED TO 1-PHENYL-3-AMINOPYRAZOLES, USING OXYGEN AND/OR AIR AS THE OXIDIZING AGENT AND IN THE PRESENCE OF COPPER SALTS, OPTIONALLY ASSOCIATED WITH METALLIC COPPER AND/OR AN AROMATIC, HETEROCYCLIC ORGANIC
