66001-90-9Relevant academic research and scientific papers
Catalytic redox amidations of aldehydes with a polymer-supported peptide-N-heterocyclic carbene multifunctional catalyst
Gondo, Chenaimwoyo A.,Bode, Jeffrey W.
, p. 1205 - 1210 (2013)
We have prepared an oligomeric histidine-bound N-heterocyclic carbene precursor by coupling a carboxylic acid functionalized 1,2,4-triazolium salt to a peptide using solid-phase peptide synthesis. We have demonstrated that the resulting multifunctional resin-bound catalyst cooperatively facilitates redox amidation reactions of aldehydes and amines, a reaction not catalyzed by N-heterocyclic carbenes alone. Georg Thieme Verlag Stuttgart New York.
