66021-66-7

Upstream product

• 536-57-2 p-toluene sulfinic acid 
• 1593-60-8 p-toluenesulfonylhydroxylamine 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 56410-24-3 N,N'-bis(p-toluenesulfonyl)hydroxylamine 
• 62419-04-9 bis(4-methylphenylsulfonyl)amino 4-methylbenzenesulfonate 
• 67-68-5 dimethyl sulfoxide 
• 3699-01-2 4-tolyl phenyl sulfide 
• 945-51-7 1,1'-sulfinylbisbenzene 
• 14065-22-6 1-methoxy-2-(phenylthio)benzene 
• 1600-44-8 1-oxothiolane 
• 21948-75-4 2-methylsulfinylpyridine 
• 940-12-5 p-nitrophenyl methyl sulfoxide 
• 1193-82-4 racemic methyl phenyl sulfoxide 
• 139-66-2 diphenyl sulfide 
• 3517-99-5 1-methoxy-4-(methylsulfinyl)benzene 
• 1593-60-8 p-toluenesulfonylhydroxylamine 
• 106-39-8 bromochlorobenzene 

Relevant academic research and scientific papers

Carbonic anhydrase inhibitors. Part 37. Novel classes of isozyme I and II inhibitors and their mechanism of action. Kinetic and spectroscopic investigations on native and cobalt-substituted enzymes

The interaction of Zn(II)- and Co(II)-carbonic anhydrase (CA) with a series of compounds possessing moieties resembling the aromatic sulfonamides, such as sulfamide, sulfamic acid, N-substituted aromatic sulfonamides, sulfenamides, sulfinic and seleninic acids, was investigated using kinetic and spectroscopic techniques. All these compounds inhibit the hydrasic and esterasic activity of the enzyme. Their binding within the active site of isozymes I and II is discussed on the basis of modifications of electronic and 1H-NMR spectra of their adducts with the Co(II) enzyme. Some of these compounds represent novel classes of CA inhibitors, possessing equal or stronger potencies than the prototypical inhibitors, the unsubstituted sulfonamides. Qualitative structure-activity correlations are discussed.

Physical Properties and Various Reactions of Thionitrites and Related Substances

Several new sulfenyl or sulfonyl derivatives, thionitrates (RSNO2), sulfonyl nitrites (RSO2NO), were successfully isolated by treating corresponding thiols and sulfinic acids with dinitrogen tetraoxide (N2O4).Spectroscopic data of both stable and many rather unstable compounds were determined and compared with those of corresponding alkyl nitrites (RONO) or alkyl nitrates (RONO2).Chemical reactivities of these uncommon, novel S-nitroso and S-nitro compounds were investigated.