66022-60-4

Basic information

• Product Name: 1-Pentene, 1-nitro-, (1E)-
• CAS NO: 66022-60-4
• Molecular Formula: C5H9NO2
• Molecular Weight: 115.132
• Mol File: 66022-60-4.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: 1-Pentene, 1-nitro-, (1E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pentene, 1-nitro-, (1E)-(66022-60-4)
• EPA Substance Registry System: 1-Pentene, 1-nitro-, (1E)-(66022-60-4)

Safety Data

• Hazardous Substances Data: 66022-60-4(Hazardous Substances Data)

Upstream product

• 109-67-1 1-penten 
• 75-52-5 nitromethane 
• 123-72-8 butyraldehyde 
• 2224-37-5 1-nitropentan-2-ol 
• 60-29-7 diethyl ether 
• 3428-90-8 2-acetoxy-1-nitro-pentane 

Downstream Products

• 67102-28-7 1-Phenyl-3-propyl-4-nitro-1-butin 
• 2013-12-9 D-norvaline 
• 251464-53-6 (R)-3-((R)-1-Aminomethyl-butyl)-4-phenyl-oxazolidin-2-one 
• 206068-37-3 (R)-2-((R)-2-Oxo-4-phenyl-oxazolidin-3-yl)-pentanoic acid 
• 1100765-13-6 C₁₉H₂₆N₂O₆ 
• 1252062-50-2 C₁₂H₁₃BrO 
• 1252062-46-6 C₁₂H₁₄BrNO₃ 
• 1295509-58-8 (R)-4-(1-nitropentan-2-yl)-1,7-diphenylhepta-1,6-diene-3,5-dione 
• 1440199-76-7 4-fluoro-3-methyl-4-(1-nitropentan-2-yl)-1-phenyl-1H-pyrazol-5(4H)-one 

Relevant articles and documents

Enantiocomplementary Michael Additions of Acetaldehyde to Aliphatic Nitroalkenes Catalyzed by Proline-Based Carboligases

The blockbuster drug Pregabalin is widely prescribed for the treatment of painful diabetic neuropathy. Given the continuous epidemic growth of diabetes, the development of sustainable synthesis routes for Pregabalin and structurally related pharmaceutically active γ-aminobutyric acid (GABA) derivatives is of high interest. Enantioenriched γ-nitroaldehydes are versatile synthons for the production of GABA derivatives, which can be prepared through a Michael-type addition of acetaldehyde to α,β-unsaturated nitroalkenes. Here we report that tailored variants of the promiscuous enzyme 4-oxalocrotonate tautomerase (4-OT) can accept diverse aliphatic α,β-unsaturated nitroalkenes as substrates for acetaldehyde addition. Highly enantioenriched aliphatic (R)- and (S)-γ-nitroaldehydes were obtained in good yields using two enantiocomplementary 4-OT variants. Our results underscore the synthetic potential of 4-OT for the preparation of structurally diverse synthons for bioactive analogues of Pregabalin.

A Nickel-Bisdiamine Porous Organic Polymer as Heterogeneous Chiral Catalyst for Asymmetric Michael Addition to Aliphatic Nitroalkenes

We report a polystyrene-incorporated chiral nickel(II)-bisdiamine complex, which is accessible on gram-scale. This metal complex functions as a heterogeneous catalyst for the enantioselective Michael addition between malonates and aliphatic nitroalkenes,

CuI-Catalysed Enantioselective Alkyl 1,4-Additions to (E)-Nitroalkenes and Cyclic Enones with Phosphino-Oxazoline Ligands

Catalytic enantioselective conjugate additions of simple alkyl groups to nitroalkenes or cyclic enones that result in the formation of tertiary C–C bonds are described. For these stereoselective addition reactions, new chiral phosphino-oxazoline ligands w