66031-88-7Relevant academic research and scientific papers
Dehydration-hydration of α-alkynols over zeolite catalyst. Selective synthesis of conjugated enynes and α,β-unsaturated ketones
Sartori, Giovanni,Pastorio, Andrea,Maggi, Raimondo,Bigi, Franca
, p. 8287 - 8296 (2007/10/03)
α-Alkynols 1 are convened in high yield and selectivity into conjugated enynes 2 or α,β-unsaturated ketones 3 by treatment with acid zeolites. The exclusive production of compounds 2 or 3 depends on the nature of the starting material 1 and experimental conditions.
Process for preparation of adjacently disubstituted ketones
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, (2008/06/13)
A novel 7-hydroxyprostaglandin E1, or a stereoisomer thereof, or a protected derivative thereof, having the following formula: STR1 wherein R8 represents H, CH3 or C2 H5, R9 represents H or CH3, R10 and R11 are identical or different, and each represents H, tetrahydropyranyl or t-butyldimethylsilyl. Also provided is a process for producing an adjacently disubstituted ketone including the above compounds, i.e. 7-oxoprostaglandin, etc. which comprises reacting an α,β-unsaturated carbonyl compound with a cuprous salt and an organolithium compound in an aprotic inert organic medium in the presence of trialkylphosphine, the amounts of said cuprous salt and said organolithium compound being substantially equimolar, and reacting the product with a protected acetal derivative of an organic carbonyl compound or an aldehyde in the presence of a Lewis acid, if necessary, followed by reacting the product with a proton donor.
