66040-38-8Relevant academic research and scientific papers
Synthesis, resolution, stereochemistry, and molecular modeling of (R)- and (S)-2-acetyl-1-(4′-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline AMPAR antagonists
Gitto, Rosaria,Ficarra, Rita,Stancanelli, Rosanna,Guardo, Marta,De Luca, Laura,Barreca, Maria Letizia,Pagano, Benedetta,Rotondo, Archimede,Bruno, Giuseppe,Russo, Emilio,De Sarro, Giovanbattista,Chimirri, Alba
, p. 5417 - 5423 (2008/03/15)
Recently we identified (R,S)-2-acetyl-1-(4′-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (6) as a potent non-competitive AMPA receptor antagonist able to prevent epileptic seizures. We report here the optimized synthesis of compound 6, its r
Synthesis of carbon-11 and fluorine-18 labeled N-acetyl-1-aryl-6,7- dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as new potential PET AMPA receptor ligands
Gao, Mingzhang,Kong, Deyuan,Clearfield, Abraham,Zheng, Qi-Huang
, p. 2229 - 2233 (2007/10/03)
New carbon-11 and fluorine-18 labeled N-acetyl-1-aryl-6,7-dimethoxy-1,2,3, 4-tetrahydroisoquinoline derivatives were designed and synthesized as potential positron emission tomography AMPA (2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl) propionic acid) recep
Discovery of a novel and highly potent noncompetitive AMPA receptor antagonist
Gitto, Rosaria,Barreca, Maria Letizia,De Luca, Laura,De Sarro, Giovambattista,Ferreri, Guido,Quartarone, Silvana,Russo, Emilio,Constanti, Andrew,Chimirri, Alba
, p. 197 - 200 (2007/10/03)
N-Acetyl-1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives were designed and synthesized as potential noncompetitive AMPA receptor antagonists on the basis of molecular modeling studies. Sound-induced seizure testing showed that this class o
