66040-43-5

Upstream product

• 14301-31-6 2-chloro-N-(2-(3,4-dimethoxyphenyl)ethyl)acetamide 
• 555-16-8 4-nitrobenzaldehdye 
• 47281-61-8 6,7-dimethoxy-1-(4'-nitrophenyl)-1,2,3,4-tetrahydrioisoquinoline 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 910108-69-9 2-(diethylaminoacetyl)-6,7-dimethoxy-1-(4-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline 
• 910108-82-6 1-[6,7-dimethoxy-1-(4-nitro-phenyl)-3,4-dihydro-1H-isoquinolin-2-yl]-2-morpholin-4-yl-ethanone 
• 910108-75-7 1-[6,7-dimethoxy-1-(4-nitro-phenyl)-3,4-dihydro-1H-isoquinolin-2-yl]-2-piperidin-1-yl-ethanone 

Relevant academic research and scientific papers

Novel potent anticonvulsant agent containing a tetrahydroisoquinoline skeleton

In our studies on the development of new anticonvulsants, we planned the synthesis of N-substituted 1,2,3,4-tetrahydroisoquinolines to explore the structure-activity relationships. All derivatives were evaluated against audiogenic seizures in DBA/2 mice,

Improved methods for the synthesis of N-acyltetrahydroisoquinolines

One-pot procedures for the synthesis of N-acyltetrahydroisoquinolines have been developed from 2-phenylethylamines, acyl chlorides or carboxylic acids and aldehydes.