66040-50-4

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 27644-76-4 2-(p-methoxyphenyl)-4,4-dimethyloxazolidine 

Downstream Products

• 93949-35-0 N-(4-methoxybenzyl)-3,4-dimethoxyphenylethylamine 
• 55580-65-9 6,7-dimethoxy-1-(4'-methoxyphenyl)-1,2,3,4-tetrahydrioisoquinoline 
• 66040-39-9 N-acetyl-6,7-dimethoxy-1-(4'-methoxyphenyl)-1,2,3,4-tetrahydrioisoquinoline 

Relevant academic research and scientific papers

An acid-free Pictet-Spengler reaction using deep eutectic solvents (DES)

Deep eutectic solvents (such as the combination of either urea or glycerol with choline chloride) are effective solvents/organocatalysts for Pictet-Spengler condensations to form carbolines. The reaction conditions are quite mild and do not require additi

Synthesis of 1-aryltetrahydroisoquinoline alkaloids and their analogs

Three alkaloids of the cryptostylin series and 20 monomolecular and 3 bimolecular 1-aryltetrahydroisoquinoline derivatives were prepared using the Picte-Spengler reaction.

Synthesis and structure - Active relationship of 1-aryl-6,7-dimethoxy-1,2, 3,4-tetrahydroisoquinoline anticonvulsants

We have previously disclosed that some 6,7-dimethoxyisoquinoline derivatives are able to produce anticonvulsant effects in different animal models of epilepsy. Following these studies this paper describes the synthesis of a small series of new 1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines strictly related to previously reported analogues. This novel series of isoquinolines was designed on the basis of well defined structure-active relationship (SAR) information already acquired for this class of anticonvulsant agents. The pharmacological effects of the new synthesized compounds were evaluated against audiogenic seizures in Dilute Brown non-Agouti (DBA/2) mice. The preliminary pharmacological screening led to the identification of a new active molecule the 2-acetyl-1-(4′-methylphenyl)-6,7-dimethoxy-1,2,3,4- tetrahydroisoquinoline (6d) that displayed significant anticonvulsant activity. Computational studies helped to rationalize these obtained pharmacological results.

1-Aryl-tetrahydroisoquinoline analogs as active anti-HIV agents in vitro

A series of 1-aryl-6,7-dihydroxyl(methoxy)-1,2,3,4-tetrahydroisoquinolines (compounds 1-36) were synthesized via Pictet-Spengler cyclization. All the synthesized compounds were assayed for activities against HIV-1IIIB in C8166 cell cultures by

Development of the Pictet-Spengler reaction catalyzed by AuCl 3/AgOTf

Mild and efficient AuCl3/AgOTf-catalyzed Pictet-Spengler reactions were developed to afford in good yields a variety of tetrahydroisoquinoline and tetrahydro-β-carboline ring systems, which constitute important motifs in biologically active nat

Synthesis of carbon-11 and fluorine-18 labeled N-acetyl-1-aryl-6,7- dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as new potential PET AMPA receptor ligands

New carbon-11 and fluorine-18 labeled N-acetyl-1-aryl-6,7-dimethoxy-1,2,3, 4-tetrahydroisoquinoline derivatives were designed and synthesized as potential positron emission tomography AMPA (2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl) propionic acid) recep

3,4-DIHYDROISOQUINOLINIUM SALT DERIVATIVES

The present invention relates to 3,4-dihydroisoquinolinium salt derivatives. More specifically, the present invention relates to 3,4-dihydroisoquinolinium salt derivatives of the following chemical formula (I).

SYNTHESIS BASED ON &β-PHENYLETHYLAMINES. IV. SYNTHESIS AND ANTIARRHYTHMIC ACTIVITY OF SUBSTITUTED PHENYLALKYLAMINES AND N-BENZYLTETRAHYDROISOQUINOLINES

A number of N-benzyltetrahydroisoquinolines forming analogues of sendaverine have been synthesized.Results on the pharmacological activity of the compounds synthesized are presented.

Carbon-transfer Reactions with Heterocycles. Part 3. Synthetic Equivalence of Oxazolidines with Carbonyl Compounds

Oxazolidines perform acid catalysed transfer of their C(2) units at the carbonyl group oxidation level to various nucleophiles, resulting in the synthesis of various heterocycles including some β-carboline and isoquinoline alkaloids.