660404-71-7Relevant academic research and scientific papers
Structural Analysis and Optimization of NK1 Receptor Antagonists through Modulation of Atropisomer Interconversion Properties
Albert, Jeffrey S.,Ohnmacht, Cyrus,Bernstein, Peter R.,Rumsey, William L.,Aharony, David,Alelyunas, Yun,Russell, Daniel J.,Potts, William,Sherwood, Scott A.,Shen, Lihong,Dedinas, Robert F.,Palmer, William E.,Russell, Keith
, p. 519 - 529 (2004)
We have previously described a series of antagonists that showed high potency and selectivity for the NK1 receptor. However, these compounds also had the undesirable property of existing as a mixture of interconverting rotational isomers. Here
