660414-40-4Relevant academic research and scientific papers
Indolizines as novel potent inhibitors of 15-Lipoxygenase
Gundersen, Lise-Lotte,Malterud, Karl E.,Negussie, Ayele H.,Rise, Frode,Teklu, Solomon,stby, Ole Benny
, p. 5409 - 5415 (2007/10/03)
15-Lipoxygenase (15-LO) has been implicated in oxidation of low-density lipoproteins (LDL) and this enzyme may be involved in the development of atherosclerosis. We have examined 1-substituted indolizines as possible inhibitors of 15-LO from soy beans and from rabbit reticulocytes. Most compounds studied were significantly more active as inhibitors of 15-LO from soy beans than quercetin. The indolizines were slightly less potent inhibitors of the mammalian enzyme, but we found good correlation between inhibitory activity against both 15-LO enzymes studied. Several of the compounds were only weak DPPH scavengers and they may therefore be regarded as so-called non antioxidant inhibitors of 15-LO.
