660440-56-2

Upstream product

• 4282-46-6 3-(4'-nitrophenyl)pyridine 
• 103983-89-7 3-(4-nitro-phenyl)-pyridine-1-oxide 

Downstream Products

• 1366518-00-4 3-{4-[3-(4-nitrophenyl)-2-oxo-2H-pyridin-1-ylmethyl]phenyl}propionic acid ethyl ester 
• 660440-04-0 3-(4-{2-oxo-3-[4-(3-o-tolyl-ureido)-phenyl]-2H-pyridin-1-ylmethyl}-phenyl)-propionic acid methyl ester 
• 884348-02-1 3-{4-[3-(4-aminophenyl)-2-oxo-2H-pyridin-1-ylmethyl]phenyl}propionic acid methyl ester 
• 884348-01-0 3-{4-[3-(4-nitro-phenyl)-2-oxo-2H-pyridin-1-ylmethyl]-phenyl}-propionic acid methyl ester 

Relevant academic research and scientific papers

Pyridone derivatives as potent and selective VLA-4 integrin antagonists

A novel series of pyridone inhibitors has been identified through pharmacophore analysis, as potent antagonists of VLA-4.

NOVEL COMPOUNDS

The present invention relates to novel pyridone derivatives capable of inhibiting a4 integrin medicated cell adhesion, processes for their preparation, compositions comprising them and their use in the treatment of diseases capable of being modulated by t