4282-46-6

Basic information

• Product Name: 3-(4-NITROPHENYL)PYRIDINE
• Synonyms: 3-(4-NITROPHENYL)PYRIDINE;3-(4'-Nitrophenyl)piridine;3-(4-Nitrophenyl)Pyridine(WX609928)
• CAS NO: 4282-46-6
• Molecular Formula: C₁₁H₈N₂O₂
• Molecular Weight: 200.19
• Product Categories: pharmacetical
• Mol File: 4282-46-6.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 364.6 °C at 760 mmHg
• Flash Point: 174.3 °C
• Appearance: /
• Density: 1.252g/cm³
• Vapor Pressure: 3.49E-05mmHg at 25°C
• Refractive Index: 1.611
• CAS DataBase Reference: 3-(4-NITROPHENYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-NITROPHENYL)PYRIDINE(4282-46-6)
• EPA Substance Registry System: 3-(4-NITROPHENYL)PYRIDINE(4282-46-6)

Safety Data

• Hazardous Substances Data: 4282-46-6(Hazardous Substances Data)

Usage

General Description

3-(4-Nitrophenyl)pyridine is a chemical compound with the chemical formula C11H8N2O2. It is a yellow crystalline solid that is commonly used in organic synthesis as a building block for more complex molecules. 3-(4-Nitrophenyl)pyridine has a nitro group attached to a phenyl ring, as well as a pyridine ring, which makes it useful for a variety of applications in the pharmaceutical and agrochemical industries. 3-(4-Nitrophenyl)pyridine is also known for its fluorescent properties, making it useful as a fluorescent probe in biological studies. 3-(4-Nitrophenyl)pyridine is typically handled with care due to its potentially harmful effects on human health and the environment.

InChI:InChI=1/C11H8N2O2/c14-13(15)11-5-3-9(4-6-11)10-2-1-7-12-8-10/h1-8H

Upstream product

• 1008-88-4 3-phenylpyridine 
• 7664-93-9 sulfuric acid 
• 100-00-5 4-chlorobenzonitrile 
• 329214-79-1 3-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 586-78-7 para-nitrophenyl bromide 
• 1692-25-7 3-pyridylboronic acid 
• 636-98-6 p-nitrobenzene iodide 
• 110-86-1 pyridine 
• 7409-30-5 p-nitrobenzylamine 
• 626-60-8 3-Chloropyridine 
• 24067-17-2 4-nitrophenylboronic acid 
• 626-55-1 3-Bromopyridine 
• 59020-10-9 3-(tributylstannyl)pyridine 
• 10400-19-8 3-pyridinecarbonyl chloride 

Downstream Products

• 154164-36-0 4-(3-pyridyl)acetanilide 
• 167959-19-5 2-nitro-4-(pyridin-3-yl)benzenamine 
• 154164-35-9 N-(4-(pyridin-3-yl)phenyl)acetamide 
• 445012-62-4 4-(pyridin-3-yl)benzene-1,2-diamine 
• 1038915-60-4 (3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine 
• 1430055-41-6 2-{4-(pyridin-3-yl)phenylazo}phenylamine 
• 1430055-31-4 5-bromo-2-{4-(pyridin-3-yl)phenylazo}phenylamine 
• 1430055-56-3 5-{10-(quinolin-3-yl)anthracen-9-yl}-2-{4-(pyridin-3-yl)phenyl}-2H-benzotriazole 
• 1430055-55-2 4,6-bis(phenanthren-2-yl)-2-{4-(pyridin-3-yl)phenyl}-2H-benzotriazole 
• 1430055-54-1 5-{4-(10-phenylanthracen-9-yl)phenyl}-2-{4-(pyridin-3-yl)phenyl}-2H-benzotriazole 
• 1430055-53-0 5-[10-{3-(naphthalen-1-yl)phenyl}anthracen-9-yl]-2-{4-(pyridin-3-yl)phenyl}-2H-benzotriazole 
• 1430055-52-9 4,6-bis(9-phenyl-9H-carbazol-3-yl)-2-{4-(pyridin-3-yl)phenyl}-2H-benzotriazole 

Relevant articles and documents

S-triazine compounds as well as preparation method and application thereof

The invention discloses s-triazine compounds and pharmaceutically acceptable salts thereof; experiments prove that the compounds can be used for treating or preventing diseases related to protein kinase activity, such as leukemia and lymphoma, by inhibiti

Synthesis method of S-3-(4-aminophenyl) piperidine

The invention relates to a synthesis method of S-3-(4-aminophenyl) piperidine. The synthetic method of the S-3-(4-aminophenyl) piperidine includes the following steps: taking 3-pyridineboronic acid (I) as a raw material, and preforming Suzuki coupling wit

Design, synthesis, and evaluation of potent Wnt signaling inhibitors featuring a fused 3-ring system

The Wnt signaling pathway is a critical developmental pathway which operates through control of cellular functions such as proliferation and differentiation. Aberrant Wnt signaling has been linked to the formation and metastasis of tumors. Porcupine, a member of the membrane-bound O-acyltransferase family of proteins, is an important component of the Wnt pathway. Porcupine catalyzes the palmitoylation of Wnt proteins, a process needed for their secretion and activity. Here we report a novel series of compounds obtained by a scaffold hybridization strategy from a known porcupine inhibitor class. The leading compound 59 demonstrated subnanomolar inhibition of Wnt signaling in a paracrine cellular assay. Compound 59 also showed excellent chemical, plasma and liver microsomal stabilities. Furthermore, compound 59 exhibited good pharmacokinetic profiles with 30% oral bioavailability in rat. Collectively, these results strongly support further optimization of this novel scaffold to develop better Wnt pathway inhibitors.