4282-46-6

Usage

Uses

Used in Pharmaceutical Industry:
3-(4-Nitrophenyl)pyridine is used as a key intermediate in the synthesis of pharmaceutical compounds for its ability to form complex molecular structures that can exhibit therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, 3-(4-Nitrophenyl)pyridine is utilized as a precursor in the development of agrochemicals, contributing to the creation of molecules with pesticidal or herbicidal properties.
Used as a Fluorescent Probe in Biological Studies:
3-(4-Nitrophenyl)pyridine is employed as a fluorescent probe due to its inherent fluorescent properties, which allow it to be used in various biological assays and imaging techniques for studying cellular processes and interactions.

InChI:InChI=1/C11H8N2O2/c14-13(15)11-5-3-9(4-6-11)10-2-1-7-12-8-10/h1-8H

Upstream product

• 13689-05-9 dinicotinoyl-peroxide 
• 98-95-3 nitrobenzene 
• 110-86-1 pyridine 
• 456-27-9 4-nitrobenzenediazonium tetrafluoroborate 
• 7664-93-9 sulfuric acid 
• 1692-25-7 3-pyridylboronic acid 
• 586-78-7 para-nitrophenyl bromide 
• 100-05-0 4-nitrobenzenediazonium chloride 
• 626-60-8 3-Chloropyridine 
• 24067-17-2 4-nitrophenylboronic acid 
• 626-55-1 3-Bromopyridine 
• 59020-10-9 3-(tributylstannyl)pyridine 
• 100-00-5 4-chlorobenzonitrile 
• 636-98-6 p-nitrobenzene iodide 

Downstream Products

• 19733-56-3 3-(4-aminophenyl)piperidine 
• 103983-89-7 3-(4-nitro-phenyl)-pyridine-1-oxide 
• 1038915-60-4 (3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine 
• 1430055-41-6 2-{4-(pyridin-3-yl)phenylazo}phenylamine 
• 1430055-31-4 5-bromo-2-{4-(pyridin-3-yl)phenylazo}phenylamine 
• 1430055-56-3 5-{10-(quinolin-3-yl)anthracen-9-yl}-2-{4-(pyridin-3-yl)phenyl}-2H-benzotriazole 
• 1430055-55-2 4,6-bis(phenanthren-2-yl)-2-{4-(pyridin-3-yl)phenyl}-2H-benzotriazole 
• 1430055-54-1 5-{4-(10-phenylanthracen-9-yl)phenyl}-2-{4-(pyridin-3-yl)phenyl}-2H-benzotriazole 
• 1430055-53-0 5-[10-{3-(naphthalen-1-yl)phenyl}anthracen-9-yl]-2-{4-(pyridin-3-yl)phenyl}-2H-benzotriazole 

Relevant academic research and scientific papers

S-triazine compounds as well as preparation method and application thereof

The invention discloses s-triazine compounds and pharmaceutically acceptable salts thereof; experiments prove that the compounds can be used for treating or preventing diseases related to protein kinase activity, such as leukemia and lymphoma, by inhibiti

Synthesis method of 3-(4-nitrophenyl)pyridine

The invention relates to a synthesis method of 3-(4-nitrophenyl)pyridine. The synthesis method of the 3-(4-nitrophenyl)pyridine comprises the following steps: S1, under the protection of inert gas, mixing 4-nitrophenylboronic acid, 3-chloropyridine, n-het

Synthesis method of S-3-(4-aminophenyl) piperidine

The invention relates to a synthesis method of S-3-(4-aminophenyl) piperidine. The synthetic method of the S-3-(4-aminophenyl) piperidine includes the following steps: taking 3-pyridineboronic acid (I) as a raw material, and preforming Suzuki coupling wit

Synthesis of Bi(hetero)aryls via Sequential Oxidation and Decarboxylation of Benzylamines in a Batch/Fully Automated Continuous Flow Process

Catalytic dehydrogenative cross-coupling of two C–H bonds represents a green strategy in view of the atom- and step-economy. However, the challenge is to discover a new innovative bond strategy, especially for the direct coupling between Csp2–H

Design, synthesis, and evaluation of potent Wnt signaling inhibitors featuring a fused 3-ring system

The Wnt signaling pathway is a critical developmental pathway which operates through control of cellular functions such as proliferation and differentiation. Aberrant Wnt signaling has been linked to the formation and metastasis of tumors. Porcupine, a member of the membrane-bound O-acyltransferase family of proteins, is an important component of the Wnt pathway. Porcupine catalyzes the palmitoylation of Wnt proteins, a process needed for their secretion and activity. Here we report a novel series of compounds obtained by a scaffold hybridization strategy from a known porcupine inhibitor class. The leading compound 59 demonstrated subnanomolar inhibition of Wnt signaling in a paracrine cellular assay. Compound 59 also showed excellent chemical, plasma and liver microsomal stabilities. Furthermore, compound 59 exhibited good pharmacokinetic profiles with 30% oral bioavailability in rat. Collectively, these results strongly support further optimization of this novel scaffold to develop better Wnt pathway inhibitors.

NOVEL NAPHTHOTRIAZOLE DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE ELEMENT

Naphthotriazole derivatives represented by the following general formula (1), wherein, Ar 1 is an aromatic hydrocarbon group or an aromatic heterocyclic group, and A is a group that contains an aromatic heterocyclic group. The compound features excellent electron injection/transporting capability, a high hole-blocking power and a high stability in the form of a thin film, and can be used as a material for producing highly efficient and highly durable organic electroluminescent devices.

FAK AND FLT3 INHIBITORS

The use of a compound of the formula (I): (Formula (I)) in the preparation of a medicament for treating Acute Myeloid Leukemia or a disease ameliorated by the inhibition of Flt3, or Flt3 and FAK.

NEW BENZOTRIAZOLE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT IN WHICH SAID DERIVATIVE IS USED

Benzotriazole derivatives represented by the following general formula (1), wherein Ar1 and Ar2 are, for example, aromatic hydrocarbon groups or aromatic heterocyclic ring groups, and A is a group including a pyridine ring. The compounds excel in electron injection/transport capability, feature a high hole-blocking power and a high stability in their thin-film form, and are useful as materials for producing highly efficient and highly durable organic electroluminescent devices.

PYRAZINE KINASE INHIBITORS

Provided are pyrazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

NAPHTHALENE DERIVATIVE

The present invention provides compounds which can regulate VCP activity. The present invention provides the compound of formula (I) (R is as defined in the description) or oxides, esters, prodrugs, pharmaceutically acceptable salts or solvates thereof. The compounds can regulate VCP activity, and thus are useful for treating VCP-mediated diseases such as neurodegenerative diseases.