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Myoinositol-monomannosid, also known as α-D-mannosidase, is an enzyme that plays a crucial role in the breakdown of complex carbohydrates, specifically in the catabolism of glycoproteins and glycolipids. It is involved in the hydrolysis of terminal α-1,2, α-1,3, and α-1,6-D-mannose residues from mannooligosaccharides and glycoconjugates. This enzyme is essential for the proper functioning of the endoplasmic reticulum-associated degradation (ERAD) pathway, which is responsible for the degradation of misfolded proteins. Myoinositol-monomannosid is a key component in maintaining cellular homeostasis and has potential therapeutic applications in the treatment of certain lysosomal storage disorders, such as I-cell disease, where the enzyme's activity is impaired.

6605-49-8

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6605-49-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 6605-49-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,6,0 and 5 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 6605-49:
(6*6)+(5*6)+(4*0)+(3*5)+(2*4)+(1*9)=98
98 % 10 = 8
So 6605-49-8 is a valid CAS Registry Number.

6605-49-8Relevant academic research and scientific papers

Creation of an α-mannosynthase from a broad glycosidase scaffold

Yamamoto, Keisuke,Davis, Benjamin G.

supporting information; experimental part, p. 7449 - 7453 (2012/09/21)

α-Mannosides made easy: Mutation of a family-GH31 α-glucosidase that displays plasticity to alterations at the 2-OH position of donor substrates created an efficient α-mannoside-synthesizing biocatalyst. A simple fluoride donor reagent was used for the synthesis of a range of mono-α-mannosylated conjugates using the α-mannosynthase displaying low (unwanted) oligomerization activity. Copyright

DERIVATIVES OF ASYMMETRICALLY SUBSTITUTED MYO-INOSITOL. XXXIII. SYNTHESIS OF DIASTEROMERIC MANNOSIDES OF MYO-INOSITOL

Sibrikov, Yu. I.,Stepanov, A. E.,Shvets, V. I.

, p. 470 - 476 (2007/10/02)

Diastereomeric acetylated mannosides of myo-inositol were synthesized by the glycosylation of the racemic acetates of myo-inositol with the ethyl orthoacetate of D-mannose.The synthesized mannosides of myo-inositol can be used for the production of chiral myo-inositol acetates and as intermediates in the synthesis of complex phosphoinositides.

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