66050-03-1

Upstream product

• 100-46-9 benzylamine 
• 935-79-5 cis-1,2,3,6-tetrahydrophthalic anhydride 
• 1469-48-3 cis-1,2,3,6-Tetrahydrophthalimide 
• 100-44-7 benzyl chloride 

Downstream Products

• 95455-15-5 rel-(3R,3aS,7aR)-2-benzyl-3-ethoxy-2,3,3a,4,7,7a-hexahydro-1-isoindolone 
• 95455-18-8 rel-(1R,2R)-11-benzyl-10-vinylidene-11-azatricyclo<5.3.2.0^2,7>-4-dodecen-12-one 
• 95455-17-7 rel-(3R,3aS,7aR)-2-benzyl-3-ethoxy-2,3,3a,4,7,7a-hexahydro-7a-<5-(trimethylsilyl)-3-pentynyl>-1-isoindolone 
• 117416-29-2 N-benzyl-4-ethylidenecyclohexanecarboxamide 
• 80818-48-0 N-benzyl-cis-8-azabicyclo<4.3.0>nonan-7-one 
• 80818-48-0 N-benzyl-trans-8-azabicyclo<4.3.0>nonan-7-one 
• 80818-41-3 N-benzyl-8-azabicyclo<4.3.0>non-1(6)-en-7-one 
• 80818-46-8 N-benzyl-cis-8-azabicyclo<4.3.0>non-3-en-7-one 
• 80818-46-8 N-benzyl-trans-8-azabicyclo<4.3.0>non-3-en-7-one 

Relevant academic research and scientific papers

NOVEL APPROACH TO TRANS-FUSED CARBOBICYCLES

The combination of a silicon directed N-acyliminium ion cyclization reaction and a subsequent SN2' substitution of an imide nitrogen with lithium dimethyl cuprate constitutes a novel approach to funcionalized trans-fused carbobicycles.

N-alkylation of imides using phase transfer catalysts under solvent-free conditions

(Chemical Equation Presented) N-Alkylation of imides in the reaction of imides and alkylhalides, catalyzed by PT catalysts under solvent-free conditions, has been developed. The reaction occurs in the presence of K 2CO3, and in many cases it takes place spontaneously. In the N-benzylation reaction, it has been recognized that TBAB (tetrabutylammonium bromide) and TBATFB (tetrabutylammonium tetrafluoroborate) show highest catalytic effect. Versatility and synthetic capacity of the solvent-free alkylation has been confirmed by N-benzylation and N-ethylation of various imides. The developed procedure gives easy access to N-(ω-bromoalkyl) imides.

QUINOLONE ANTIBACTERIAL AGENTS

Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.

Synthesis of conformationally defined glutamic acid analogues from readily available Diels-Alder adducts

New amino acids, (±)-t-3,t-4-bis(carboxymethyl)-r-2- pyrrolidinecarboxylic acid (1d) and (±)-t-3a,t-6a-perhydro-r-1,t-4,t-6- cyclopenta[c]pyrroletricarboxylic acid (2), which possess relatively similar configurations to kainic acid, were synthesized from readily available Diels- Alder adducts.