66050-90-6

Upstream product

• 33442-47-6 (S)-2-phenylbutan-1-ol 
• 39637-99-5 (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride 
• 2035-94-1 2-phenylbutan-1-ol 
• 675855-20-6 (4S)-4-isopropyl-2-[(2R,E)-2-phenyl-3-decenyl]-4,5-dihydro-1,3-oxazole 
• 675855-28-4 (R,E)-3-phenyl-4-undecenoic acid 
• 675855-29-5 (R,E)-3-phenyl-4-undecen-1-ol 
• 675855-30-8 (3R,4E)-3-phenyl-4-undecene 

Relevant academic research and scientific papers

N-heterocyclic carbene-mediated enantioselective addition of phenols to unsymmetrical alkylarylketenes

Chiral N-heterocyclic carbenes (NHCs) mediate the enantioselective addition of 2-phenylphenol to unsymmetrical alkylarylketenes, delivering α-alkyl-α-arylacetic acid derivatives with good levels of enantiocontrol (up to 84% ee). Enantiodivergent stereochemical outcomes are observed using 2-phe-nylphenol and benzhydrol in the NHC-promoted esterification reaction using a triazolium precatalyst derived from pyroglutamic acid, consistent with distinct mechanistic pathways operating within these processes.

Stereoselective Construction of Acyclic Carbon Chains by a One-Pot Coupling Process Based on Alkenyloxazoline-Titanium Complexes

A versatile organometallic intermediate, an alkenyloxazoline-titanium complex, has been developed that enables one-pot multicomponent diastereoselective and asymmetric coupling processes to be achieved in a remarkably efficient manner (see scheme).