66056-40-4

Usage

Uses

Used in Pharmaceutical Synthesis:
2-[2,4-Bis(benzyloxy)phenyl]acetic Acid is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs. Its unique structure allows for the creation of complex molecules that can target specific biological pathways, potentially leading to more effective treatments.
Used in Organic Material Synthesis:
In the field of organic materials, 2-[2,4-Bis(benzyloxy)phenyl]acetic Acid is used as a building block for the synthesis of various organic compounds. Its presence in these materials can enhance their properties, such as stability, reactivity, or specific functional groups, making them suitable for a range of applications.
Used in Organic Chemistry Research:
2-[2,4-Bis(benzyloxy)phenyl]acetic Acid is utilized as a research compound in organic chemistry. Its reactivity and structural features make it an interesting subject for studying reaction mechanisms, exploring new synthetic routes, and understanding the properties of related compounds.
Used in Drug Discovery:
In the realm of drug discovery, 2-[2,4-Bis(benzyloxy)phenyl]acetic Acid is used as a starting material or a component in the design of novel drug candidates. Its potential applications in this field highlight its importance in the development of new therapeutic agents that can address unmet medical needs.
Overall, 2-[2,4-Bis(benzyloxy)phenyl]acetic Acid is a versatile and potentially valuable chemical compound with a wide range of potential applications in various fields of science and industry, including pharmaceuticals, organic materials, organic chemistry research, and drug discovery.

Upstream product

• 115692-62-1 1-Allyl-2,4-bis-benzyloxy-benzene 
• 151255-80-0 2,4-dibenzyloxyphenylacetic acid methyl ester 
• 23931-69-3 (S)-2-(4-Methoxy-benzyloxycarbonylamino)-succinamic acid 4-nitro-phenyl ester 
• 113954-23-7 2,4-dibenzyloxyphenylacetonitrile 
• 100-44-7 benzyl chloride 
• 113954-22-6 2,4-di(benzyloxy)benzyl chloride 
• 33617-58-2 2,4-dibenzyloxybenzyl alcohol 
• 100-39-0 benzyl bromide 
• 22877-01-6 2,4-bis(benzyloxy)acetophenone 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 13246-46-3 2,4-dibenzyloxybenzaldehyde 

Downstream Products

• 115692-56-3 2,4-dibenzyloxyphenylacetic acid p-nitrophenyl ester 
• 113978-98-6 dibenzyl-2,4-dihydroxyphenylacetic acid N-hydroxysuccinimide ester 
• 614-82-4 (2,4-dihydroxyphenyl)acetic acid 
• 193008-72-9 3-(2,4-bis-benzyloxy-phenyl)-7-hydroxy-chromen-2-one 
• 113954-20-4 (S)-N¹-(5-Amino-pentyl)-2-[2-(2,4-dihydroxy-phenyl)-acetylamino]-succinamide; hydrochloride 
• 113954-21-5 (S)-N¹-{3-[4-(3-Amino-propylamino)-butylamino]-propyl}-2-[2-(2,4-dihydroxy-phenyl)-acetylamino]-succinamide; hydrochloride 
• 113954-19-1 (S)-N¹-(5-{3-[3-(3-Amino-propylamino)-propylamino]-propionylamino}-pentyl)-2-[2-(2,4-dihydroxy-phenyl)-acetylamino]-succinamide; hydrochloride 
• 113954-18-0 (S)-N¹-(5-{3-[4-(3-Amino-propylamino)-butylamino]-propionylamino}-pentyl)-2-[2-(2,4-dihydroxy-phenyl)-acetylamino]-succinamide; hydrochloride 
• 113954-15-7 (S)-N¹-(5-Amino-pentyl)-2-[2-(2,4-bis-benzyloxy-phenyl)-acetylamino]-succinamide 
• 128507-45-9 1-[2-(2,4-dibenzyloxyphenylacetyl)aminoethyl]piperidine 
• 128507-49-3 1-(2,4-dibenzyloxyphenylacetyl)-4-benzylpiperazine 
• 122841-92-3 1-(2,4-dibenzyloxyphenylacetyl-L-asparaginyl)-4-phenylpiperazine 
• 122841-93-4 1-(2,4-dibenzyloxyphenylacetyl-L-glutaminyl)-4-benzylpiperazine 
• 122841-91-2 1-(2,4-dibenzyloxyphenylacetyl-L-glutaminyl)-4-phenylpiperazine 

Relevant academic research and scientific papers

The total large-scale synthesis of argiopine

The total large-scale synthesis of a natural toxin argiopine, a polymethylenepolyamine derivative, was developed. It consisted of 26 stages and included three key block schemes. Most of the stages proceeded quantitatively, which excluded the necessity of using the chromatographic separation of intermediates.

Selective endothelin A receptor ligands. 1. Discovery and structure-activity of 2,4-disubstituted benzoic acid derivatives

This paper describes the discovery of a new non-peptide endothelin A (ET(A)) selective ligand, 2,4-dibenzyloxybenzoic acid 3, which inhibits the binding of [125I]ET-1 to ET(A) receptors with an IC50 of 9 μM (ET-1 = endothelin-1). Optimisation of 3 resulted in compound 52 which had an IC50 of 1 μM. One of the analogues of 3, compound 15, was examined in a functional assay and shown to antagonise ET-1-induced contraction of rat aorta. The identification of 3 was made through the application of ChemDBS-3D searching of our corporate database. The 3D query, using an aromatic ring to a carboxylic acid group separated by 10.2 ± 1.1 A, was derived from an examination of common pharmacophoric distances found in the low energy conformations of two known ET(A) antagonists, the cyclic pentapeptide BQ 123 1 and myriceron caffeoyl ester 2.

Total syntheses of spidamine and joramine, polyamine toxins from the joro spider, Nephila clavata

In order to confirm the structures of spidamine and joramine, identified from the venom of a spider (nephila clavata), we convergently synthesized both compounds, which have a common side chain of N-(L-asparaginyl)-N'-(3- aminopropyl-β-alanyl)-1,5-pentanediamine. A synthon of the common side chain was synthesized by starting with n-propanolamine which was converted to 7- azido-N-benzyloxycarbonyl-4-azaheptanoic acid N-hydroxysuccinimidyl ester. The ester was coupled with tert-butyloxycarbonyl-L-asparaginyl-1,5- pentanediamine to give the synthon of the common side chain. In the final synthesis of spidamine, the synthon of the common side chain was reacted with 2,4-dibenzyloxyphenylacetic acid N-hydroxysuccinimidyl ester, obtained by Willgerodt-kindler reaction of 2,4-dihydroxyacetophenone. The protected spidamine was catalytically hydrogenated to remove protective groups, affording spidamine itself in 13% yield from n-propanolamine. In the final synthesis of joramine, the synthon of the common side chain was reacted with 4-benzyloxyphenyl acetic acid N-hydroxysuccinimidyl ester. The protected joramine was also catalytically hydrogenated to produce joramine itself in 11% yield. The conformations of both synthesized compounds were analyzed by 1H-NMR and 13C-NMR. Their blocking activities on glutamate receptors were examined using lobster neuromuscular synapses.

An efficient synthesis of JSTX-3, a potent neurotoxin of Joro spider (Nephila clavata)

JSTX-3 (Joro spider toxin-3) (1), a potent neurotoxin isolated from Joro spider (Nephila clavata), has been efficiently synthesized starting from 5-azido-1-N-Boc-pentylamine (11) via the convergent synthetic strategy in which the characteristic polyamine

Synthesis and assay of hybrid analogs of argiotoxin-636 and philanthoxin-433: Glutamate receptor antagonists

The synthesis of the non-competitive glutamate receptor antagonist, argiotoxin-636 is described. Furthermore, synthetic routes are presented for the preparation of structural analogs including argiotoxin-philanthotoxin hybrids. Biological activities on gl

Amide compounds, their production and use

A compound is provided which has the formula STR1 wherein m is an integer of 1 to 3; n is an integer of 1 or 2; p is an integer of 1 or 2; q is an integer of 1 to 6; x is an integer of 2 to 6; Ph is phenylene or a pharmceutically acceptable salt thereof. Also provided is a method for glutamate receptor inhibition which comprises administering to a mammal in need thereof an effective amount of said compound or a pharmaceutically acceptable salt thereof. Compositions for glutamate receptor inhibition are provided which contain an effective amount of said compound to provide a glutamate receptor inhibition effect, together with at least one pharmaceutically acceptable carrier, dilient or excipient therefor.

N-heterocyclic amides

A compound of the formula: STR1 wherein STR2 represents a cyclic amino group, A represents a methylene group or a carbonyl group, m represents an integer of 1 to 3, n represents an integer of 0 to 4 and p represents an integer of 1 to 2, or a salt thereof, which has glutamate receptor inhibiting activity is provided.

Glutamate receptor inhibitor and insecticidal composition

A compound of the formula STR1 wherein R' is hydrogen atom or an alkyl group, m is an integer of 1 to 3, p is 1 or 2, x is an integer of 2 to 6, and y is an integer of 1 to 3, or a salt thereof, which has glutamate receptor inhibitor activity, a process for preparing the same and an insecticidal composition containing the same are provided.

SYNTHESIS OF SPIDER TOXIN (JSTX-3) AND ITS ANALOGS

One of the active principles isolated from spider venom, JSTX-3, and its analogs of the polyamine part were synthesized.