66056-40-4

Basic information

• Product Name: 2-[2,4-Bis(benzyloxy)phenyl]acetic Acid
• Synonyms: 2-[2,4-Bis(benzyloxy)phenyl]acetic Acid
• CAS NO: 66056-40-4
• Molecular Weight: 348.398
• Mol File: 66056-40-4.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2-[2,4-Bis(benzyloxy)phenyl]acetic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2,4-Bis(benzyloxy)phenyl]acetic Acid(66056-40-4)
• EPA Substance Registry System: 2-[2,4-Bis(benzyloxy)phenyl]acetic Acid(66056-40-4)

Safety Data

• Hazardous Substances Data: 66056-40-4(Hazardous Substances Data)

Usage

General Description

2-[2,4-Bis(benzyloxy)phenyl]acetic Acid is a chemical compound with the molecular formula C23H22O4. It is a derivative of acetic acid and contains two benzyl ether groups attached to a phenyl ring. 2-[2,4-Bis(benzyloxy)phenyl]acetic Acid is often used in the synthesis of pharmaceuticals and organic materials. It may also have potential applications in the field of organic chemistry and drug discovery. The compound's structure and reactivity make it a valuable building block for the creation of more complex molecules, and its properties may make it useful for a variety of research purposes. Overall, 2-[2,4-Bis(benzyloxy)phenyl]acetic Acid is a versatile and potentially valuable chemical compound with a wide range of potential applications in various fields of science and industry.

Upstream product

• 115692-62-1 1-Allyl-2,4-bis-benzyloxy-benzene 
• 113954-23-7 2,4-dibenzyloxyphenylacetonitrile 
• 23931-69-3 (S)-2-(4-Methoxy-benzyloxycarbonylamino)-succinamic acid 4-nitro-phenyl ester 
• 100-44-7 benzyl chloride 
• 113954-22-6 2,4-di(benzyloxy)benzyl chloride 
• 33617-58-2 2,4-dibenzyloxybenzyl alcohol 
• 100-39-0 benzyl bromide 
• 22877-01-6 2,4-bis(benzyloxy)acetophenone 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 13246-46-3 2,4-dibenzyloxybenzaldehyde 
• 151255-80-0 2,4-dibenzyloxyphenylacetic acid methyl ester 

Downstream Products

• 115692-56-3 2,4-dibenzyloxyphenylacetic acid p-nitrophenyl ester 
• 113954-20-4 (S)-N¹-(5-Amino-pentyl)-2-[2-(2,4-dihydroxy-phenyl)-acetylamino]-succinamide; hydrochloride 
• 113954-21-5 (S)-N¹-{3-[4-(3-Amino-propylamino)-butylamino]-propyl}-2-[2-(2,4-dihydroxy-phenyl)-acetylamino]-succinamide; hydrochloride 
• 113954-19-1 (S)-N¹-(5-{3-[3-(3-Amino-propylamino)-propylamino]-propionylamino}-pentyl)-2-[2-(2,4-dihydroxy-phenyl)-acetylamino]-succinamide; hydrochloride 
• 113954-18-0 (S)-N¹-(5-{3-[4-(3-Amino-propylamino)-butylamino]-propionylamino}-pentyl)-2-[2-(2,4-dihydroxy-phenyl)-acetylamino]-succinamide; hydrochloride 
• 113954-15-7 (S)-N¹-(5-Amino-pentyl)-2-[2-(2,4-bis-benzyloxy-phenyl)-acetylamino]-succinamide 
• 122841-92-3 1-(2,4-dibenzyloxyphenylacetyl-L-asparaginyl)-4-phenylpiperazine 
• 122841-93-4 1-(2,4-dibenzyloxyphenylacetyl-L-glutaminyl)-4-benzylpiperazine 
• 122841-91-2 1-(2,4-dibenzyloxyphenylacetyl-L-glutaminyl)-4-phenylpiperazine 
• 122841-89-8 1-(2,4-dibenzyloxyphenylacetyl-L-glutaminyl)-4-methylpiperazine 

Relevant articles and documents

The total large-scale synthesis of argiopine

The total large-scale synthesis of a natural toxin argiopine, a polymethylenepolyamine derivative, was developed. It consisted of 26 stages and included three key block schemes. Most of the stages proceeded quantitatively, which excluded the necessity of using the chromatographic separation of intermediates.

Total syntheses of spidamine and joramine, polyamine toxins from the joro spider, Nephila clavata

In order to confirm the structures of spidamine and joramine, identified from the venom of a spider (nephila clavata), we convergently synthesized both compounds, which have a common side chain of N-(L-asparaginyl)-N'-(3- aminopropyl-β-alanyl)-1,5-pentanediamine. A synthon of the common side chain was synthesized by starting with n-propanolamine which was converted to 7- azido-N-benzyloxycarbonyl-4-azaheptanoic acid N-hydroxysuccinimidyl ester. The ester was coupled with tert-butyloxycarbonyl-L-asparaginyl-1,5- pentanediamine to give the synthon of the common side chain. In the final synthesis of spidamine, the synthon of the common side chain was reacted with 2,4-dibenzyloxyphenylacetic acid N-hydroxysuccinimidyl ester, obtained by Willgerodt-kindler reaction of 2,4-dihydroxyacetophenone. The protected spidamine was catalytically hydrogenated to remove protective groups, affording spidamine itself in 13% yield from n-propanolamine. In the final synthesis of joramine, the synthon of the common side chain was reacted with 4-benzyloxyphenyl acetic acid N-hydroxysuccinimidyl ester. The protected joramine was also catalytically hydrogenated to produce joramine itself in 11% yield. The conformations of both synthesized compounds were analyzed by 1H-NMR and 13C-NMR. Their blocking activities on glutamate receptors were examined using lobster neuromuscular synapses.

Synthesis and assay of hybrid analogs of argiotoxin-636 and philanthoxin-433: Glutamate receptor antagonists

The synthesis of the non-competitive glutamate receptor antagonist, argiotoxin-636 is described. Furthermore, synthetic routes are presented for the preparation of structural analogs including argiotoxin-philanthotoxin hybrids. Biological activities on gl