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66074-00-8

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66074-00-8 Usage

General Description

1,2,5-Oxadiazole, 3,4-bis(phenylsulfonyl)-, 2-oxide is a chemical compound that belongs to the oxadiazole family. It is a white to pale yellow crystalline powder with the chemical formula C14H10N2O6S2. 1,2,5-Oxadiazole, 3,4-bis(phenylsulfonyl)-, 2-oxide has applications in the field of organic synthesis and pharmaceuticals. It can be used as a building block for the synthesis of various biologically active compounds and pharmaceutical drugs. Additionally, it possesses interesting properties that make it suitable for use in materials science and as a potential pharmaceutical intermediate. Its unique structure and reactivity make it a valuable compound in various chemical and biological applications.

Check Digit Verification of cas no

The CAS Registry Mumber 66074-00-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,0,7 and 4 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 66074-00:
(7*6)+(6*6)+(5*0)+(4*7)+(3*4)+(2*0)+(1*0)=118
118 % 10 = 8
So 66074-00-8 is a valid CAS Registry Number.

66074-00-8Relevant articles and documents

Synthesis of lathyrane diterpenoid nitrogen-containing heterocyclic derivatives and evaluation of their anti-inflammatory activities

Wang, Wang,Xiong, Liangliang,Li, Yutong,Song, Zhuorui,Sun, Dejuan,Li, Hua,Chen, Lixia

, (2022/01/24)

As our ongoing work on lathyrane diterpenoid derivatization, three series of lathyrane diterpenoid derivatives were designed and synthesized based combination principles, including pyrazole, thiazole and furoxan moieties. Biological evaluation indicated t

Design, synthesis and biological activity evaluation of novel scopoletin-NO donor derivatives against MCF-7 human breast cancer in vitro and in vivo

Chen, Li,Deng, Qi,Lei, Zhichao,Li, Na,Sun, Jianbo,Wang, Kun,Yu, Nairong

, (2021/07/28)

In this study, eleven new 3- and 7-positions modified scopoletin derivatives (18a-k) were designed, synthesized, and biologically evaluated against human breast cancer cell lines. Most compounds showed improved antiproliferative activity against MCF-7 and MDA-MB-231 cells and weaker cytotoxicity on human breast epithelial cell line MCF-10A than lead compound 5. Among them, compound 18e exhibited the most potent antiproliferative activity against MCF-7 cells (IC50 = 0.37 ± 0.05 μM). Particularly, 18e produced the highest levels of nitric oxide (NO) intracellularly, and its antiproliferation effect was attenuated by hemoglobin (an NO scavenger). Further pharmacological research showed that 18e blocked the cell cycle at the G2/M phase, downregulated the phosphorylation of PI3K and Akt in MCF-7 cells and regulated the expressions of the apoptosis proteins to induce apoptosis. Moreover, 18e inhibited the growth of MCF-7 in vivo. Overall, 18e is a novel anticancer agent with the abilities of high concentration of NO releasing and the inhibition of PI3K/Akt signaling pathway, and may be a promising agent against MCF-7 human breast cancer.

Chromone 3-position nitric oxide donor derivative as well as preparation method and application thereof

-

, (2021/05/05)

The invention relates to the fields of natural medicines and medicinal chemistry, and relates to a preparation method of a series of chromone 3-position nitric oxide donor derivatives with antitumor activity and a new application of the chromone 3-position nitric oxide donor derivatives in preparation of antitumor medicines. The chromone 3-position nitric oxide donor derivative and the pharmaceutically acceptable salt thereof are shown as a general formula I in the specification. Wherein R and R1 are described in the claims and the specification.

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