66081-21-8

Upstream product

• 203932-90-5 2-azidobenzenesulfonyl chloride 
• 88-21-1 2-amino-1-benzenesulfonic acid 
• 71236-07-2 2-azidobenzenesulfonic acid 
• 3306-62-5 2-AMINOBENZENESULFONAMIDE 

Downstream Products

• 155763-78-3 methyl 2-[[[2-butyl-1-[(4-((((2-azidophenyl)sulfonyl)amino)carbonyl)phenyl)methyl]-1H-imidazol-5-yl]methyl]amino]benzoate 
• 23822-74-4 3-benzyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide 
• 3306-78-3 3-phenyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide 
• 3306-80-7 3-(4-methoxyphenyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide 
• 1026709-51-2 C₃₀H₄₅N₂O₃PS₂ 
• 329347-49-1 C₂₄H₄₁N₂O₃PS 
• 329347-52-6 C₂₄H₃₉N₂O₃PS 

Relevant academic research and scientific papers

An one-pot approach to the synthesis of triazolobenzothiadiazepine 1,1-dioxide derivatives by basic alumina-supported azide-alkyne [3+2] cycloaddition

An efficient one-pot strategy for the synthesis of triazolobenzothiadiazepine 1,1-dioxide derivatives has been developed by the reaction of 2-azido-N-substituted benzenesulfonamides and propargyl bromide in basic alumina under microwave condition via [3+2] azide-alkyne cycloaddition reaction. This protocol has synthetic advantages in terms of low environmental impact and short reaction time.

Synthesis of 3-amino-1,2,4-benzothiadiazine 1,1-dioxides via a tandem aza-Wittig/heterocumulene annulation

Reaction of o-azidobenzenesulfonamides with polymer-supported triphenylphosphine affords the corresponding iminophosphoranes. Subsequent reaction with isocyanates gives 3-amino-1,2,4-benzothiadiazine 1,1-dioxides in high yields and purities. The reaction

The synthesis of pyrrolo[1,2-b][1,2,5]benzothiadiazepines from 1,2-thiazine 1-oxides - Sulfonamide analogues of the pyrrolobenzodiazepine antitumour natural products

Pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) and the corresponding pyrrolobenzothiadiazepines (PBTDs) are attractive targets as natural and synthetic antitumour antibiotics and as non-nucleosidic reverse transcriptase inhibitors. A concise synthesis of the P

A thiazine-S-oxide, Staudinger/aza-Wittig based synthesis of benzodiazepines and benzothiadiazepines

A new approach to the synthesis of imine containing 1,2,5-benzothiadiazepine-1,1-dioxides and 1,4-benzodiazepin-5-ones using iminophosphoranyl thiazine-S-oxides as precursors is reported. Key steps include a Staudinger reaction, an aza-Wittig reaction and

3H-Azepines and Related Systems. Part 2. The Photolyses of Aryl Azides Bearing Electron-withdrawing Substituents

The photolyses of ortho-substituted aryl azides (o-XC6H4N3 where X = CONHNH2, CONHN=CHAr, NO2, CN, CF3, SO2OMe, SO2NH2, or SO2Ph) in methanol-tetrahydrofuran solution are described.With X = CF3 or CONHN=CHAr, 3-substituted 2-methoxy-3H-azepines are products, while in other cases polymeric products, amines or mixtures of isomeric azepines are obtained.The product from the photolysis of o-azidophenyl phenyl sulphoxide (X = SOPh) is identified tentatively (n.m.r. evidence) as 7-methoxy-2-phenylsulphinyl-3H-azepine.In contrast, methyl p-azidobenzoate and p-cyanophenyl azide yield the corresponding 5-substituted 2-methoxy-3H-azepines, whereas methyl m-azidobenzoate yields only methyl 2-methoxy-3H-azepine-6-carboxylate.Irradiation of methyl o-azidobenzoate in aqueous tetrahydrofuran gives 1,3-dihydro-3-methoxycarbonyl-2H-azepin-2-one.