66095-18-9

Usage

Uses

Used in Pharmaceutical Industry:
BENZYL N-(6-AMINOHEXYL)CARBAMATE HYDROCHLORIDE is used as a reactant in the synthesis of SIB-DOTA, a compound that enhances the uptake of monoclonal antibodies by tumors. This application is particularly important in the field of oncology, as it can improve the effectiveness of targeted therapies for cancer treatment.
In the synthesis of SIB-DOTA, BENZYL N-(6-AMINOHEXYL)CARBAMATE HYDROCHLORIDE plays a critical role by providing a stable and biocompatible platform for the attachment of monoclonal antibodies. This allows for the development of more effective cancer therapies that can specifically target and destroy tumor cells while minimizing damage to healthy tissues.
Furthermore, the use of BENZYL N-(6-AMINOHEXYL)CARBAMATE HYDROCHLORIDE in the synthesis of SIB-DOTA also contributes to the advancement of drug delivery systems. By enhancing the uptake of monoclonal antibodies by tumors, BENZYL N-(6-AMINOHEXYL)CARBAMATE HYDROCHLORIDE can potentially improve the efficacy and safety of various cancer treatments, leading to better patient outcomes and overall survival rates.

Upstream product

• 124-09-4 1,6-Hexanediamine 
• 28170-07-2 benzyl phenyl carbonate 
• 501-53-1 benzyl chloroformate 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 

Downstream Products

• 98577-69-6 {6-[4-(6-Benzyloxycarbonylamino-hexylcarbamoyl)-butyrylamino]-hexyl}-carbamic acid benzyl ester 
• 98577-74-3 {6-[3-Benzyloxycarbonylamino-4-(6-benzyloxycarbonylamino-hexylcarbamoyl)-butyrylamino]-hexyl}-carbamic acid benzyl ester 
• 162877-50-1 6-benzyloxy-carbonylamino-1-(p-nitrophenyloxycarbonyl)aminohexane 
• 253877-82-6 N,N'-di[6-{[(benzyloxy)carbonyl]amino}hexyl]-1,1'-biphenyl-4,4'-diyldiamide 
• 616886-01-2 [6-(3-methoxybenzylamino)hexyl]carbamic acid benzyl ester 
• 616885-92-8 (6-benzylaminohexyl)carbamic acid benzyl ester 
• 428879-77-0 6-(2-methoxybenzylamino)hexanoic acid (6-{6-[6-(2-methoxybenzylamino)hexanoylamino]hexanoylamino}hexyl)amide 
• 428879-75-8 (5-{6-[6-(6-benzyloxycarbonylaminohexanoylamino)hexanoylamino]hexylcarbamoyl}pentyl)carbamic acid benzyl ester 
• 162877-51-2 (S)-2-[3-(6-Benzyloxycarbonylamino-hexyl)-ureido]-pentanedioic acid di-tert-butyl ester 
• 322001-06-9 C₄₉H₆₉N₇O₈ 

Relevant academic research and scientific papers

Novel bivalent ligands carrying potential antinociceptive effects by targeting putative mu opioid receptor and chemokine receptor CXCR4 heterodimers

The functional interactions between opioid and chemokine receptors have been implicated in the pathological process of chronic pain. Mounting studies have indicated the possibility that a MOR-CXCR4 heterodimer may be involved in nociception and related ph

TRIPODAL SQUARAMIDE-BASED MONOMERS

The present invention relates to a tripodal squaramide-based monomer based monomer according to formula (I) for the formation of supramolecular polymers: wherein T represents a central atom; n is an integer of from 4 to 12; and R1 is a group ac

Solid-Phase-Based Synthesis of Ureidopyrimidinone-Peptide Conjugates for Supramolecular Biomaterials

Supramolecular polymers have shown to be powerful scaffolds for tissue engineering applications. Supramolecular biomaterials functionalized with ureidopyrimidinone (UPy) moieties, which dimerize via quadruple hydrogen-bond formation, are eminently suitable for this purpose. The conjugation of the UPy moiety to biologically active peptides ensures adequate integration into the supramolecular UPy polymer matrix. The structural complexity of UPy-peptide conjugates makes their synthesis challenging and until recently low yielding, thus restricted the access to structurally diverse derivatives. Here we report optimization studies of a convergent solid-phase based synthesis of UPy-modified peptides. The peptide moiety is synthesized using standard Fmoc solid-phase synthesis and the UPy fragment is introduced on the solid-phase simplifying the synthesis and purification of the final UPy-peptide conjugate. The convergent nature of the synthesis reduces the number of synthetic steps in the longest linear sequence compared to other synthetic approaches. We demonstrate the utility of the optimized route by synthesizing a diverse range of biologically active UPy-peptide bioconjugates in multimilligram scale for diverse biomaterial applications. 1 Introduction 2 Divergent Synthesis 3 Convergent Synthesis 4 UPy-Amine Strategy 5 UPy-Carboxylic Acid Strategy 6 Conclusion.

Ligand-directed selective protein modification based on local single-electron-transfer catalysis

A photocatalyst ([Ru(bpy)3]2+) bound to a protein ligand was essential for the title method. Local single-electron transfer from the catalyst resulted in the formation of tyrosyl radicals. N′-Acetyl-N,N- dimethyl-1,4-phenylenediamine was used as the tyrosyl radical trapping agent and used in a radical addition to afford selective modification of the target protein. Copyright

Synthesis and characterization of well-defined l-lactic acid-caprolactone co-oligomers and their rhenium (I) and technetium(I) conjugates

Staring from l-lactide and ε-caprolactone, the corresponding lactic-caprolactone cooligomer with hydroxyl and carboxylic acid groups were synthesized. These oligomers were connected with chelating groups through a long chain tether, ready for transition metal binding. Coordination of organometallic rhenium(I) and technetium(I) complexes generated the conjugates in high yield and short time, satisfying the requirements for short-lived radiopharmaceuticals in clinical applications. A reasonable pharmacophore model has been established to guide the design of well-defined lactic acid oligomer for nuclear medicine.

Role of the guanidine group in the N-terminal fragment of PTH(1-11)

A series of PTH hybrids containing a diamine [NH2(CH 2) n NH2; n = 4, 5, 6] in the C-terminal position was synthesized based on the H-Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln- Har-NH2 (Har = homoargini

ORGANIC COMPOUNDS USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES, USES AND METHODS FOR THE PREPARATION THEREOF

Compounds having a general formula (I) are used for the treatment of neurodegenerative diseases, wherein at least one of R1 ed R8 is chosen from the group consisting of (II), (III), (V), (VI), (XVII).

2, 5-Bis-Diamine [1,4] Benzoquinone-Derivatives

Synthesis of 2,5-bis-diamine-[1,4]benzoquinonic derivatives having the general formula (I), products and intermediates of said synthesis; the synthesis involves the use of p-benzoquinones having the general formula (IX) and diamines having the general for

Selective synthesis of carbamate protected polyamines using alkyl phenyl carbonates

Utilising alkyl phenyl carbonates, an economical, practical and versatile method for selective Boc, Cbz and Alloc protection of polyamines has been developed. This method allows Boc, Cbz and Alloc protection of primary amines in the presence of secondary amines by reaction of the polyamines with the alkyl phenyl carbonates. Also, this method allows mono carbamate protection of simple symmetrical aliphatic α,ω-alkanediamines in high yields with respect to the diamine. Finally, the method allows selective carbamate protection of a primary amine located on a primary carbon in the presence of a primary amine located on a secondary or a tertiary carbon in excellent yields.