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4,4,4-trifluoro-3-hydroxy-3-methylbutan-2-one is a complex organic compound with the molecular formula C5H7F3O2. It is a colorless liquid with a molecular weight of 168.1 g/mol. 4,4,4-trifluoro-3-hydroxy-3-methylbutan-2-one is characterized by the presence of a trifluoromethyl group (CF3), a hydroxyl group (OH), and a methyl group (CH3) attached to a butan-2-one backbone. The compound exhibits unique chemical properties due to the presence of fluorine atoms, which can influence its reactivity, stability, and physical properties. It is primarily used in the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals, where its unique structure can provide specific benefits. The compound's stability and reactivity can be influenced by the electron-withdrawing nature of the fluorine atoms, which can affect its behavior in chemical reactions.

661-78-9

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661-78-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 661-78-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,6 and 1 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 661-78:
(5*6)+(4*6)+(3*1)+(2*7)+(1*8)=79
79 % 10 = 9
So 661-78-9 is a valid CAS Registry Number.

661-78-9Downstream Products

661-78-9Relevant academic research and scientific papers

Diketo compounds with (trifluoromethyl)trimethylsilane: Double nucleophilic trifluoromethylation reactions

Singh,Leitch,Twamley,Shreeve

, p. 1436 - 1440 (2001)

Reactions of various diketo compounds with (trifluoromethyl)trimethylsilane (Me3SiCF3) in the presence of catalytic amounts of cesium fluoride have been studied. γ-Ketoesters, CH3COCH2CH2CO2R (R = Et, Bu), were reacted with 2 equiv of Me3SiCF3 at room temperature to give CH3C(OH)(CF3)CH2CH2 COCF3 in good yield after hydrolysis, α-Diketones, R1COCOR2 (R1 = R2 = Ph; R1 = Ph, R2 = Me; R1 = R2 = Me, R2 = Me, R2 = Et), when reacted with Me3SiCF3, formed 1:1 or 1:2 addition products depending on the reaction conditions and stoichiometry used. Reactions of diones CH3COXCOCH3 (X = -CH2CH2-, -C6H4C6H4-, -CH2-) with Me3SiCF3 also led to the formation of the mono- or diaddition products depending on reaction conditions. With various kinds of substituted arylglyoxals, 2 equiv of Me3SiCF3 produced monoaddition products in 70-75% yield and diaddition products in 5-10% yield. One of the monoalcohols and two of the diols have been characterized by single-crystal X-ray analysis, and the presence of inter- and intramolecular hydrogen bonding has been confirmed.

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