66104-32-3

Usage

InChI:InChI=1/C10H11NO2S/c1-6(12)11-8-2-3-9(13)10-7(8)4-5-14-10/h4-5,8H,2-3H2,1H3,(H,11,12)

Upstream product

• 58094-12-5 N-acetyl-4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine 
• 7732-18-5 water 
• 71-48-7 cobalt(III) acetate 
• 58094-06-7 N-formyl-4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine 
• 108-10-1 4-methyl-2-pentanone 

Relevant academic research and scientific papers

Process for preparing 4,5,6,7-tetrahydro-7-oxobenzo[b]thiophenes and 1,2,3,4-tetrahydro-4-oxonaphthalenes

There is provided a process for the preparation of an amido or an ureido derivative of certain 4,5,6,7-tetrahydro-7-oxobenzo[b]thiophenes or certain 1,2,3,4-tetrahydro-4-oxonaphthalenes which can be employed as an animal growth regulant. The process comprises: oxidizing in the presence of a cobalt catalyst a compound having the formula: STR1 wherein R1 and R2 are each a substituent selected from the group consisting of alkanoyl C1 -C7, halogen-substituted alkanoyl C1 -C7, carboalkoxy C1 -C4, STR2 and STR3 R3 is selected from the group consisting of hydrogen and alkyl C1 -C4 ; R4 is selected from the group consisting of hydr ogen, alkyl C1 -C8, alkanoyl C2 -C4, halogen-substituted alkanoyl (C2 -C4), and STR4 and when the STR5 moiety is cyclized each represents a moiety selected from the group consisting of succinimido, maleimido and phthalimido; X and Y are each a radical selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, nitro, alkyl C1 -C4 ; the racemic mixtures and the optical isomers thereof.

Process for preparation 4,5,6,7-tetrahydro-7-oxobenzo-[b]-thiophenes and 1,2,3,4-tetrahydro-4-oxo-1-naphthalenes

There is provided an oxidation process using potassium permanganate as oxidizing agent, for the preparation of certain animal growth promoters, namely, N-(4,5,6,7-tetrahydro-7-oxobenzo[b]thien-4-yl)amides, 4,5,6,7-tetrahydro-7-oxobenzo[b]-thien-4-ylureas, N-(1,2,3,4-tetrahydro-4-oxo-1-naphthyl)amides and 1,2,3,4-tetrahydro-4-oxo-1-naphthylureas, said process affording such compounds in markedly improved yields, and being readily suitable for scale-up.

Process for oxidation of 4-amidotetrahydrobenzo [b]-thiophenes to 7-keto derivatives with cobaltic salts

There is provided a process for the preparation of an amido or an ureido derivative of certain 4,5,6,7-tetrahydro-7-oxobenzo[b]thiophenes or certain 1,2,3,4-tetrahydro-4-oxonaphthalenes which can be employed as an animal growth regulant. The process comprises: oxidizing in the presence of a cobaltic carboxylate reactant and in the absence or presence of air, a compound having the formula: STR1 wherein R1 and R2 are each a substituent selected from the group consisting of alkanoyl C1 -C7, halogen-substituted alkanoyl C1 -C7, carboalkoxy C1 -C4, STR2 and STR3 R3 is selected from the group consisting of hydrogen and alkyl C1 -C4 ; R4 is selected from the group consisting of hydrogen, alkyl C1 -C8, alkanoyl C2 -C4, halogen-substituted alkanoyl (C2 -C4), and STR4 and when the STR5 moiety is cyclized each represents a moiety selected from the group consisting of succinimido, maleimido and phthalimido; X and Y are each a radical selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, nitro, alkyl C1 -C4 ; the racemic mixtures and the optical isomers thereof.

Novel 4,5,6,7-tetrahydro-7-oxy(oxy)benzo [b]thiophen-4-amine compounds useful as animal growth regulants

This invention relates to novel derivatives of 4,5,6,7-tetrahydro-7-oxo(oxy)benzo[b]thiophen-4-amine which are useful as animal growth regulants, and a process for the preparation thereof. The above-identified compounds of this invention are also useful as intermediates for the preparation of 4,5,6,7-tetrahydro-7-oxo(oxy)benzo[b]thien-4-ylurea compounds.

1-Benzoyl-3-(4,5,6,7-tetrahydrobenzo [b]thien-4-yl)ureas and 1-benzoyl-3-(4,5,6,7-tetrahydro-7-oxobenzo [b]thien-4-yl)ureas, novel intermediates for the preparation of animal growth promoting agents

This invention relates to 1-benzoyl-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea, 1-benzoyl-3-(4,5,6,7-tetrahydro-7-oxobenzo[b]thien-4-yl)urea, and derivatives thereof and a method for the preparation of said compounds and substituted derivatives. Both of the above referred-to compounds are novel and useful intermediates for the preparation of the corresponding tetrahydrobenzo[b]thien-4-ylurea and tetrahydro-7-oxobenzo[b]thien-4-ylurea, respectively. The latter compounds and certain derivatives thereof are animal growth promoting agents.