66120-29-4Relevant academic research and scientific papers
Regioselective Metal-Free Decarboxylative Multicomponent Coupling of α-Amino Acids, Aldehydes and Isonitriles Leading to N-Substituted Azacyclic-2-carboxamides with Antithrombotic Activity
Dighe, Shashikant U.,Kumar, Anil K. S.,Srivastava, Smriti,Shukla, Pankaj,Singh, Surendra,Dikshit, Madhu,Batra, Sanjay
, p. 99 - 108 (2015)
An atom-economical regioselective synthesis of N-substituted prolinamides or N-substituted piperidine-2-carboxamides via a metal-free decarboxylative multicomponent coupling between l-proline or pipecolic acid, aldehydes, and isonitriles is described. The cascade event involves sequential imine formation, decarboxylation, isonitrile insertion, and hydrolysis to afford the product in one-pot. Two of the prolinamides were found to display appreciable antithrombotic activity via inhibition of platelet aggregation.
