66147-29-3

Usage

Uses

Used in Pharmaceutical Industry:
Methotrexate α-Methyl Ester is used as an antineoplastic agent for its potential role in cancer treatment. As a folic acid antagonist, it may interfere with the synthesis of nucleic acids and proteins in rapidly dividing cells, such as cancer cells, thereby inhibiting their growth and proliferation.
Additionally, Methotrexate α-Methyl Ester is used as an antirheumatic agent for its potential role in the treatment of rheumatoid arthritis and other autoimmune diseases. Its anti-inflammatory and immunosuppressive properties may help alleviate symptoms and slow down the progression of these conditions.

Upstream product

• 52853-40-4 6-bromomethyl-2,4-diaminopteridine hydrobromide 
• 79974-20-2 (2S)-2-(4-methylaminobenzoylamino)pentanedioic acid 1-methyl ester 
• 79640-68-9 α-methyl γ-tert-butyl N-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-L-glutamate 
• 10541-83-0 N-methyl-p-aminobenzoic acid 
• 1676-73-9 L-glutamic acid γ-benzyl ester 
• 79974-16-6 N-<4-<<(benzyloxy)carbonyl>methylamino>benzoyl>-L-glutamic acid α-methyl γ-benzyl ester 
• 79974-22-4 N-<4-<<(benzyloxy)carbonyl>methylamino>benzoyl>-L-glutamic acid γ-benzyl ester 
• 66891-86-9 benzyl (4-(chlorocarbonyl)phenyl)(methyl)carbamate 
• 2528-30-5 4-<<(benzyloxy)carbonyl>methylamino>benzoic acid 
• 95485-08-8 α-methyl γ-tert-butyl N--L-glutamate 
• 6234-01-1 L-glutamic acid 5-tert-butyl 1-methyl ester hydrochloride 

Downstream Products

• 913625-15-7 6-(4-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-methoxycarbonyl-butyrylamino)-hexanoic acid tert-butyl ester 
• 913625-19-1 2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-{2-[3,4,5-triacetoxy-6-(4,5,6-triacetoxy-2-acetoxymethyl-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-2-ylmethylsulfanyl]-ethylcarbamoyl}-butyric acid methyl ester 
• 913625-16-8 6-((S)-4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-methoxycarbonyl-butyrylamino)-hexanoic acid 
• 913625-20-4 2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-{2-[3,4,5-triacetoxy-6-(4,5-diacetoxy-2-acetoxymethyl-6-fluoro-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-2-ylmethylsulfanyl]-ethylcarbamoyl}-butyric acid methyl ester 
• 913625-18-0 C₅₃H₇₁FN₁₀O₂₀S 
• 913625-17-9 2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-(5-{2-[3,4,5-triacetoxy-6-(4,5,6-triacetoxy-2-acetoxymethyl-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-2-ylmethylsulfanyl]-ethylcarbamoyl}-pentylcarbamoyl)-butyric acid methyl ester 

Relevant academic research and scientific papers

Optimized design and synthesis of chemical dimerizer substrates for detection of glycosynthase activity via chemical complementation

Glycosynthases catalyze the formation of a glycosidic bond between a glycosyl fluoride donor substrate and a glycosyl acceptor substrate with high yield, thus providing a valuable approach for the synthesis of carbohydrates and glycoconjugates. Chemical c