661489-23-2

Basic information

• Product Name: (E)-3-(4-AMino-3,5-diMethylphenyl)acrylonitrile Hydrochloride
• Synonyms: (E)-3-(4-AMino-3,5-diMethylphenyl)acrylonitrile Hydrochloride;(2E)-3-(4-AMino-3,5-diMethylphenyl)-2-propenenitrile Hydrochloride;(E)-3-(4-Amino-3,5-dimethylphenyl)-2-propenenitrile hydrochloride;AMino-3,5-diMethylphenyl)acrylonitrile Hydrochloride;acrylonitrile hydrochloride;3-(4-Amino-3,5-dimethyl-phenyl)-acrylonitrile hydrochloride
• CAS NO: 661489-23-2
• Molecular Formula: C11H13ClN2
• Molecular Weight: 209
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 661489-23-2.mol
• Article Data: 9

Chemical Properties

• Melting Point: 300 °C
• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Dichloromethane, Ethyl Acetate, Methanol, Toluene
• CAS DataBase Reference: (E)-3-(4-AMino-3,5-diMethylphenyl)acrylonitrile Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(4-AMino-3,5-diMethylphenyl)acrylonitrile Hydrochloride(661489-23-2)
• EPA Substance Registry System: (E)-3-(4-AMino-3,5-diMethylphenyl)acrylonitrile Hydrochloride(661489-23-2)

Safety Data

• Hazardous Substances Data: 661489-23-2(Hazardous Substances Data)

Usage

Uses

(E)-3-(4-AMino-3,5-diMethylphenyl)acrylonitrile Hydrochloride can be used in the preparation of 5,6-substituted pyrimidines that can possibly inhibit HIV strains resistant to reverse transcriptase inhibitors.

InChI:InChI=1S/C11H12N2.ClH/c1-8-6-10(4-3-5-12)7-9(2)11(8)13;/h3-4,6-7H,13H2,1-2H3;1H/b4-3+;

Upstream product

• 4102-53-8 4-iodo-2,6-dimethylaniline 
• 107-13-1 acrylonitrile 
• 16947-63-0 2,6-dimethyl-4-nitroaniline 
• 86955-76-2 N-(benzyloxycarbonyl)-2,6-dimethyl-4-nitroaniline 
• 87-62-7 2,6-dimethylaniline 
• 500292-86-4 3-(4-amino-3,5-dimethylphenyl)acrylonitrile 
• 114886-15-6 N'-(4-bromo-2,6-dimethylphenyl)-N,N-dimethylmethanimidamide 

Relevant articles and documents

Rilpivirine midbody preparing technology

The invention belongs to the field of medicinal chemistry, and particularly relates to a rilpivirine midbody preparing technology. The technology comprises the steps that 1, 4-bromo-2,6-dimethylaniline and acrylonitrile react under the catalysis of pallad

RILPIVIRINE HYDROCHLORIDE

The present invention provides a novel process for the preparation of rilpivirine. The present invention also provides a novel process for the preparation of rilpivirine hydrochloride. The present invention further provides a rilpivirine hydrochloride monohydrate, process for its preparation and pharmaceutical compositions comprising it.

RILPIVIRINE PROCESS

Disclosed is process for the preparation of a key Rilpivirine intermediate namely, (E)-4-(2-cyanoethenyl)-2,6-dimethylphenylamine hydrochloride (II) by a process comprising reaction of the tetrafluoroborate salt of the diazonium ion of 2,6-dimethyl-4-amin