66164-12-3Relevant academic research and scientific papers
Synthesis of 2-aminobutene-1,4-diones by gold-catalysed three-component coupling reactions
Liu, Li,Tang, Jiaqi,Qiang, Jian,He, Mingyang
, p. 247 - 249 (2016)
A gold-catalysed three-component coupling reaction of phenylglyoxal derivatives, alkynes and secondary amines was developed to provide a novel one-pot synthesis of 2-aminobutene-1,4-diones in moderate to good yields.
Substrate-controlled and highly stereoselective synthesis of 2-aminobut-2-ene-1, 4-diones
Deng, Cong,Yang, Yan,Gao, Meng,Zhu, Yan-Ping,Wu, An-Xin,Ma, Jun-Rui,Yin, Guo-Dong
, p. 3828 - 3834 (2012/07/02)
2-Methylthio-substituted 1,4-enediones, obtained from readily available aryl methyl ketones, were reacted with primary or secondary amines to afford the desired 1,4-diaryl-2-aminobut-2-ene-1,4-diones in excellent yields with high Z/E-stereoselectivity.
Bulk gold-catalyzed reactions of diazoalkanes with amines and O2 to give enamines
Zhou, Yibo,Angelici, Robert J.,Keith Woo
scheme or table, p. 8 - 15 (2010/11/24)
Bulk gold powder, consisting of approximately 5-50 μm particles, catalyzes reactions of diazoalkanes E(H)C=N2, where E is CO 2Et or PhC(O), with amines R1R2NH and O 2 to give enamine products (R1R2N)(E)C=CH(E) in 58-94% yield. The reactions are proposed to occur by initial formation of surface-bound (E)(H)C: carbene groups that are attacked by nucleophilic amines. The enamine products are very different than those obtained in reactions catalyzed by homogeneous transition metal complexes. These reactions of diazoalkanes, amines, and O2 represent a new type of bulk gold-catalyzed reaction.
