66164-33-8

Basic information

• Product Name: 4-Heptanone, 2,6-diphenyl-
• CAS NO: 66164-33-8
• Molecular Formula: C19H22O
• Molecular Weight: 266.383
• Mol File: 66164-33-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-Heptanone, 2,6-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Heptanone, 2,6-diphenyl-(66164-33-8)
• EPA Substance Registry System: 4-Heptanone, 2,6-diphenyl-(66164-33-8)

Safety Data

• Hazardous Substances Data: 66164-33-8(Hazardous Substances Data)

Upstream product

• 71254-82-5 α,α,α',α'-teteramethyldibenzyl ketone 
• 591-50-4 iodobenzene 
• 123-19-3 4-heptanone 
• 103818-68-4 N-isopropyl-3-phenylbutanamide 
• 98-83-9 isopropenylbenzene 
• 129976-22-3 2-(2-phenylpropyl)-1,3-dithiane 
• 51552-98-8 3-phenylbutanoyl chloride 

Relevant articles and documents

Ketone Synthesis by Direct, Orthogonal Chemoselective Hydroacylation of Alkenes with Amides: Use of Alkenes as Surrogates of Alkyl Carbanions

Direct functionalization of alkenes and direct transformation of carboxamides are two exciting areas that have attracted considerable attention in recent years. We report herein that secondary amides, the least reactive derivatives of carbonyl compounds, upon activated with triflic anhydride, can serve as effective hydroacylating reagents in partner with alkenes to yield ketones at ambient temperature. The method was applied to the one-step synthesis of racemic dihydro-ar-turmerone. In this method, alkenes serve as surrogates of organometallic reagents, which allows the orthogonal chemoselective reactions. The ready availability of many olefins such as camphene and norbornene permits one-step ketone synthesis that would require several steps by conventional methods.

13C magnetic resonance studies. 142. The fate of highly substituted acyclic ketones in strong base: β-enolization, Haller-Bauer cleavage, and an alkyl to aryl acyl shift

Di-tert-butyl ketone (2a), 5,5,7,7-tetramethyl-6-undecanone (2b), and 2,4-dimethyl-2,4-diphenyl-3-pentanone (2d) have been found to undergo slow rearrangement by β-proton abstraction from the α-methyl groups upon treatment with t-BuO-/t-BuOH/>185 deg C.This is in contrast to the absence of such rearrangement in cyclic systems.It is the only significant process observed for 2a and 2b, whereas with 2d and its monomethyl analog 22 Haller-Bauer type cleavage and an unprecedented 1,3-acyl shift from sp3 to sp2 carbon accompany the β-enolate rearrangement.The rates of 1H/2H exchange of the methyl protons in 2a, b were found to be similar to those reported for a variety of cyclic systems but this exchange does not occur in 2d, where only aryl proton exchange was observed.