66166-23-2

Upstream product

• 104924-43-8 N-(2-hydroxy-2-phenyl-pentyl)-benzamide 
• 104924-39-2 2,5-Diphenyl-5-propyl-4,5-dihydro-oxazole 
• 6683-92-7 1-phenylpentan-2-one 
• 131003-71-9 N-(2-Oxo-1-phenyl-pentyl)-benzamide 
• 131003-66-2 1-Phenyl-pentane-1,2-dione 1-oxime 
• 66166-15-2 (1RS,2SR)-2-benzoylamino-1-phenyl-pentan-1-ol 

Relevant academic research and scientific papers

ISOQUINOLINE SYNTHESIS VIA 2-OXAZOLINES. PART VI. TRANSFORMATION OF 1-BENZAMIDO-1-PHENYL-2-ALKANOLS INTO 4-ALKYL-1-PHENYLISOQUINOLINES

Conditions necessary for the transformation of 1-benzamido-1-phenyl-2-alkanols (1) and 5-alkyl-2,4-diphenyl-2-oxazolines (2) into 4-alkyl-1-phenylisoquinolines (3) have been determined.The mechanism proposed for these reactions is supported by the results

ISOQUINOLINE SYNTHESES VIA 2-OXAZOLINES. PART V. SYNTHESES OF 4-ALKYL-1-PHENYLISOQUINOLINES BY PICTET-GAMS REACTION

Conditions necessary for transformation of hydroxyamides (4) and 2-oxazolines (5) into 4-alkyl-1-phenylisoquinolines have been established.The mechanism of the Pictet-Gams reaction claiming the existence of protonated oxazolines (7) and unsaturated amides

A Reinvestigation of the Pictet-Gams Isoquinoline Synthesis. Part 2. Formation of Rearranged Isoquinolines: the Δ2-Oxazoline-Isoquinoline Transformation

Cyclisation of a series of 2-substituted 2-acylamino-1-arylalkan-1-ols using phosphorus pentaoxide in refluxing decalin is shown to lead to rearranged, i.e. 4-substituted, isoquinolines in addition to the anticipated 3-substituted isomers.The products arise largely via 5-phenyl-Δ2-oxazoline intermediates and the formation of the rearranged isoquionolines from these intermediates is fully discussed.The pathway is not substantially altered when 2-benzamido-1-methoxy-1-phenylalkanes are cyclised.