66192-31-2

Upstream product

• 139437-27-7 (E)-3-(2-Cyano-phenyl)-3-phenyl-acrylic acid methyl ester 
• 2042-37-7 o-cyanobromobenzene 
• 2757-04-2 phenyl cinnamate 
• 66192-30-1 N-hydroxymethyl-3,3-diphenyl-propionamide 
• 102-92-1 cinnamoyl chloride 
• 57152-94-0 (E)-N-benzylcinnamamide 
• 621-82-9 Cinnamic acid 
• 140-10-3 (E)-3-phenylacrylic acid 
• 1493-13-6 trifluorormethanesulfonic acid 
• 119163-15-4 (E)-N,N-dibenzyl-3-phenylprop-2-enamide 
• 102-92-1 Cinnamoyl chloride 
• 100-46-9 benzylamine 
• 103-49-1 dibenzylamine 
• 19340-71-7 1-benzyl-4-phenyl-2-azetidinone 

Relevant academic research and scientific papers

The triflic acid-mediated cyclisation of N-benzylcinnamanilides

N-Benzylcinnamanilides cyclise with triflic acid to form 1-benzyl-4-aryl-2,4-dihydro-1H-quinolin-2-ones and 2,5-diaryl-benzazepin-3-ones. The product ratio is determined by the preferred orientation of the amide and by the electronics of the substituents. With ortho-substituted anilides, N-debenzylation also occurs to give 4-aryl-2,4-dihydro-1H-quinoline-2-ones.

The triflic acid-mediated cyclisation of N-benzyl-cinnamamides

N-Benzyl-cinnamamides cyclise with triflic acid to form 5-aryl-benzazepinones and/or cinnamamides.

The acid-mediated ring opening/cyclisation reaction of N-benzyl-α- aryl-azetidinones

N-Benzyl-4-aryl-azetidinones undergo ring opening with triflic acid to form N-benzyl-cinnamamides, which either undergo cyclisation to give 5-aryl-benzazepin-3-ones or N-debenzylation to give cinnamamides.

Synthesis of novel tetrahydrobenzazepinones

The synthesis of novel tetrahydrobenzazepinones 1, 2, and 3 is described, as well as an improved synthesis of 4. The palladium catalyzed arylation approach to 1, 2, and 4 allows facile entry to benzazepinones lacking electron donating substituents on the

Imidazo [1,2-b][2]benzazepine and pyrimido [1,2-b][2]benzazepine antiarrhythmic agents

Novel imidazo[1,2-b][2]benzazepines and pyrimido[1,2-b][2]benzazepines of formula I, pharmaceutical compositions containing them, methods for treating cardiac arrhythmias in mammals utilizing them, and processes for synthesizing them. STR1

1,2,4,5-Tetrahydro-3H-2-benzazepin-3-ones

New physiologically active 1,2,4,5-tetrahydro-3H-2-benzazepin-3-ones having the general formula STR1 wherein R1 is hydrogen or phenyl, R2 is hydrogen, alkyl, C3 -C6 -alkenyl, C1 -C4 -acyl,