66192-31-2

Upstream product

• 2757-04-2 phenyl cinnamate 
• 621-82-9 Cinnamic acid 
• 57152-94-0 (E)-N-benzylcinnamamide 
• 102-92-1 cinnamoyl chloride 
• 140-10-3 (E)-3-phenylacrylic acid 
• 1493-13-6 trifluorormethanesulfonic acid 
• 119163-15-4 (E)-N,N-dibenzyl-3-phenylprop-2-enamide 
• 102-92-1 Cinnamoyl chloride 
• 100-46-9 benzylamine 
• 103-49-1 dibenzylamine 
• 19340-71-7 1-benzyl-4-phenyl-2-azetidinone 
• 100-39-0 benzyl bromide 
• 5661-55-2 4-phenylazetidin-2-one 
• 66192-30-1 N-hydroxymethyl-3,3-diphenyl-propionamide 

Relevant academic research and scientific papers

The triflic acid-mediated cyclisation of N-benzylcinnamanilides

N-Benzylcinnamanilides cyclise with triflic acid to form 1-benzyl-4-aryl-2,4-dihydro-1H-quinolin-2-ones and 2,5-diaryl-benzazepin-3-ones. The product ratio is determined by the preferred orientation of the amide and by the electronics of the substituents. With ortho-substituted anilides, N-debenzylation also occurs to give 4-aryl-2,4-dihydro-1H-quinoline-2-ones.

The triflic acid-mediated cyclisation of N-benzyl-cinnamamides

N-Benzyl-cinnamamides cyclise with triflic acid to form 5-aryl-benzazepinones and/or cinnamamides.

The acid-mediated ring opening/cyclisation reaction of N-benzyl-α- aryl-azetidinones

N-Benzyl-4-aryl-azetidinones undergo ring opening with triflic acid to form N-benzyl-cinnamamides, which either undergo cyclisation to give 5-aryl-benzazepin-3-ones or N-debenzylation to give cinnamamides.

Imidazo [1,2-b][2]benzazepine and pyrimido [1,2-b][2]benzazepine antiarrhythmic agents

Novel imidazo[1,2-b][2]benzazepines and pyrimido[1,2-b][2]benzazepines of formula I, pharmaceutical compositions containing them, methods for treating cardiac arrhythmias in mammals utilizing them, and processes for synthesizing them. STR1

Synthesis of novel tetrahydrobenzazepinones

The synthesis of novel tetrahydrobenzazepinones 1, 2, and 3 is described, as well as an improved synthesis of 4. The palladium catalyzed arylation approach to 1, 2, and 4 allows facile entry to benzazepinones lacking electron donating substituents on the

1,2,4,5-Tetrahydro-3H-2-benzazepin-3-ones

New physiologically active 1,2,4,5-tetrahydro-3H-2-benzazepin-3-ones having the general formula STR1 wherein R1 is hydrogen or phenyl, R2 is hydrogen, alkyl, C3 -C6 -alkenyl, C1 -C4 -acyl,