66193-59-7

Usage

Uses

1. Used in Pharmaceutical Industry:
1-Naphthalenecarboxylic acid, 5,6,7,8-tetrahydro-, methyl ester is used as an intermediate compound for the synthesis of Palonosetron (P165830), a serotonin 5-HT3 receptor antagonist. Palonosetron is specifically utilized in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). 1-Naphthalenecarboxylic acid, 5,6,7,8-tetrahydro-, methyl ester's ability to interact with serotonin receptors makes it a valuable component in the development of antiemetic medications.
2. Used in Drug Development:
As a key intermediate in the synthesis of Palonosetron, 1-Naphthalenecarboxylic acid, 5,6,7,8-tetrahydro-, methyl ester plays a crucial role in drug development. Its unique chemical structure allows for the creation of targeted therapies that can help alleviate the side effects of chemotherapy, improving the quality of life for cancer patients undergoing treatment.

Upstream product

• 186581-53-3 diazomethane 
• 119-64-2 tetralin 
• 1066-54-2 trimethylsilylacetylene 
• 67-56-1 methanol 
• 4242-18-6 5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid 

Downstream Products

• 41790-30-1 (5,6,7,8-tetrahydronaphthalene-1-yl)methanol 
• 3506-84-1 4-(1-naphthyl)-2-butanone 

Relevant academic research and scientific papers

C-GLUCOSIDE DERIVATIVE CONTAINING FUSED PHENYL RING OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PROCESS FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

The present disclosure relates to C-glycoside derivatives having a fused phenyl ring or pharmaceutical acceptable salts thereof, a method for preparing the same, a pharmaceutical composition comprising the same, a use thereof and a method for dual inhibition of SGLT1 and SGLT2 using the same. A novel compound of the present disclosure has a dual inhibitory activity against SGLT1 and SGLT2, thus being valuably used as a diabetes therapeutic agent.

Aromatic β-silylethenylation reactions via organogallium compounds

In the presence of GaCl3, silylethyne reacted electrophilically with aromatic hydrocarbons to give β-silylethenylated arenes. The reaction proceeded via cationic species generated by the interaction of GaCl3 and silylethyne. High reactivity of the intermediate was demonstrated by the rapid reaction rate at -78 °C using close to the equimolar amount of the substrates. ipso-Substitution reaction took place with 1,2,3- trimethoxybenzene. Structures and properties of several organogallium compounds involved in the reactions are discussed.