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Usage

Uses

Used in Pharmaceutical Industry:
METHYL 2-(2-FLUORO-BIPHENYL-4YL)PROPIONATE is used as an intermediate for the synthesis of the metabolite of Flurbiprofen for its anti-inflammatory and analgesic properties. It serves as a crucial component in the development of medications aimed at reducing inflammation and alleviating pain.
Used in Anti-inflammatory Applications:
METHYL 2-(2-FLUORO-BIPHENYL-4YL)PROPIONATE is used as an active ingredient in anti-inflammatory medications, specifically for its ability to reduce inflammation and provide pain relief. Its role in the synthesis of flurbiprofen makes it an essential component in the treatment of various inflammatory conditions.
Used in Analgesic Applications:
METHYL 2-(2-FLUORO-BIPHENYL-4YL)PROPIONATE is used as a key component in the development of analgesic medications, targeting the relief of pain and discomfort. Its conversion to flurbiprofen allows for the creation of effective pain management solutions.

InChI:InChI=1/C16H15FO2/c1-11(16(18)19-2)13-8-9-14(15(17)10-13)12-6-4-3-5-7-12/h3-11H,1-2H3

Upstream product

• 67-56-1 methanol 
• 5104-49-4 fluorobiprofen 
• 1201594-47-9 C₁₂H₁₆FNO₅S 
• 98-80-6 phenylboronic acid 
• 113544-32-4 (R)-3-O-(2-(2-fluoro-4-biphenyl)propionyl)-1,2-O-isopropylidene-α-D-glucofuranose 

Downstream Products

• 5104-49-4 (R)-flurbiprofen 
• 1430219-38-7 2-{2'-fluoro-4'-[1-oxo-1-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexylamino)propan-2-yl]biphenyl-4-yloxy}ethyl nitrate 
• 1430219-39-8 3-{2'-fluoro-4'-[1-oxo-1-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexylamino)propan-2-yl]biphenyl-4-yloxy}propyl nitrate 
• 1430219-40-1 4-{2'-fluoro-4'-[1-oxo-1-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexylamino)propan-2-yl]biphenyl-4-yloxy}butyl nitrate 
• 1430219-41-2 6-{2'-fluoro-4'-[1-oxo-1-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexylamino)propan-2-yl]biphenyl-4-yloxy}hexyl nitrate 
• 1430219-42-3 2-{2'-fluoro-4'-[1-oxo-1-(8-(1,2,3,4-tetrahydroacridin-9-ylamino)octylamino)propan-2-yl]biphenyl-4-yloxy}ethyl nitrate 
• 1430219-43-4 3-{2'-fluoro-4'-[1-oxo-1-(8-(1,2,3,4-tetrahydroacridin-9-ylamino)octylamino)propan-2-yl]biphenyl-4-yloxy}propyl nitrate 
• 1430219-44-5 4-{2'-fluoro-4'-[1-oxo-1-(8-(1,2,3,4-tetrahydroacridin-9-ylamino)octylamino)propan-2-yl]biphenyl-4-yloxy}butyl nitrate 
• 1430219-45-6 6-{2'-fluoro-4'-[1-oxo-1-(8-(1,2,3,4-tetrahydroacridin-9-ylamino)octylamino)propan-2-yl]biphenyl-4-yloxy}hexyl nitrate 
• 42771-82-4 2-(2-fluoro-4-biphenylyl)-2-methylmalonic acid 
• 5104-49-4 fluorobiprofen 
• 5104-49-4 (S)-(+)-flurbiprofen 
• 1262801-25-1 C₂₇H₁₉FN₂O₄S 

Relevant academic research and scientific papers

Suzuki-Miyaura coupling of aryl carbamates, carbonates, and sulfamates

(Chemical Equation Presented) The first Suzuki-Miyaura cross-couplings of carbamates, carbonates, and sulfamates is described. The method provides a powerful means of using simple derivatives of phenol as precursors to polysubstituted aromatic compounds, as exemplified by a concise synthesis of the anti-inflammatory drug flurbiprofen.

Resolution of racemic flurbiprofen by lipase-mediated esterification in organic solvent

Resolution of rac-flurbiprofen, 2-fluoro-α-methyl-[1,1'-biphenyl]-4-acetic acid (1), by biocatalytic methodologies has been studied. Enzymatic hydrolysis of rac-flurbiprofen methyl ester (2) in aqueous-organic medium gave poor results. Transesterification of the same ester mediated by immobilized lipase from Candida antarctica (Novozym 435) in organic solvent proceeded with good enantiomeric excess but the isolation of the product required chromographic separation and therefore was unsuitable for large scale preparation. Direct esterification of 1 with methanol in acetronitrile promoted by Novozym 435 proved to be the best method since it gave, via a twofold kinetic resolution, S-flurbiprofen with excellent enantiomeric excess. The R-flurbiprofen methyl ester formed in the reaction can be converted into the starting rac-flurbiprofen by alkaline hydrolysis or, alternatively, into R-flurbiprofen by hydrolysis with acid.

ESTERS OF ARYLPROPIONIC ACIDS WITH 1,2:5,6-DI-O-ISOPROPYLIDENE- AND 1,2-O-ISOPROLYLIDENE-α-D-GLUCOFURANOSE

On fractional crystallization of 3-O-(2-(2-fluoro-4-biphenylyl)propionyl-, 3-O-(2-(4-isobutylphenyl)propionyl)- and 3-O-(2-(6-methoxy-2-naphthyl)propionyl)-1,2:5,6-di-O-isopropylidene-α-D-glucofuranoses V - VII optically pure R-diastereoisomers were isolated.The derivatives of 1,2-O-isopropylidene-α-D-glucofuranose obtained on partial deacetylation of esters V - VII were separated chromatographically to R and S-diastereoisomers.Their hydrolysis or transesterification afforded optically pure arylpropionic acids or their methyl esters, respectively.Kinetic resolutionof the acids gives rise to esters V - VII enriched in R-diastereoisomer.