66202-98-0

Usage

InChI:InChI=1/C16H23N3O5/c1-17-16(20)18-11-12(21-4)10-6-8-23-13(10)15(22-5)14(11)24-9-7-19(2)3/h6,8H,7,9H2,1-5H3,(H2,17,18,20)

Upstream product

• 52631-80-8 5-amino-4,7-dimethoxy-6-benzofuranol 
• 52631-78-4 1-(4,7-dimethoxy-6-hydroxy-5-benzofuranyl)ethanone oxime 
• 484-51-5 5-acetyl-6-hydroxy-4,7-dimethoxybenzofuran 
• 52631-79-5 N-(4,7-dimethoxy-6-hydroxy-5-benzofuranyl)acetamide 
• 66203-89-2 N-(4,7-dimethoxy-6-hydroxy-5-benzofuranyl)-N'-methylurea 
• 107-99-3 2-(dimethylamino)ethyl chloride 

Relevant academic research and scientific papers

Synthesis and Antiarrhythmic Activity of New Benzofuran Derivatives

Various 5-aminobenzofuran derivatives were prepared from khellin and screened intravenously in the dog for their potential antiarrhythmic activity against ouabain-induced ventricular arrhythmia and in the Harris test.From systematic structural variations it was found that two methoxy groups in positions 4 and 7 on the benzofuran ring, a tertiary aminoethoxy side chain in position 6, and a N-methylurea group in position 5 led to the most active compounds.These were then tested orally in the Harris test in the dog.The two long-acting derivativesN--N'-methylurea (8j) and N--N'-methylurea (8m) showed advantages when compared to quinidine and diisopyramide and have been selected for further studies.