66203-07-4

Usage

Type of Compound

Synthetic compound

Potential Properties

Anti-cancer properties

Classification

Urea derivative

Mechanism of Action

Inhibits angiogenesis (formation of new blood vessels)

Target

Signaling pathways involved in angiogenesis

Effect on Cancer Cells

Inhibits growth and spread of cancer cells

Preclinical Studies

Shown promising results as a potential treatment for various types of cancer

Field of Interest

Oncology (cancer research and treatment)

Upstream product

• 52631-79-5 N-(4,7-dimethoxy-6-hydroxy-5-benzofuranyl)acetamide 
• 52631-78-4 1-(4,7-dimethoxy-6-hydroxy-5-benzofuranyl)ethanone oxime 
• 52631-80-8 5-amino-4,7-dimethoxy-6-benzofuranol 
• 66203-89-2 N-(4,7-dimethoxy-6-hydroxy-5-benzofuranyl)-N'-methylurea 
• 484-51-5 5-acetyl-6-hydroxy-4,7-dimethoxybenzofuran 
• 66203-90-5 N-<6-(2-chloroethoxy)-4,4-dimethoxy-5-benzofuranyl>-N'-methylurea 
• 74-89-5 methylamine 

Relevant academic research and scientific papers

Synthesis and Antiarrhythmic Activity of New Benzofuran Derivatives

Various 5-aminobenzofuran derivatives were prepared from khellin and screened intravenously in the dog for their potential antiarrhythmic activity against ouabain-induced ventricular arrhythmia and in the Harris test.From systematic structural variations it was found that two methoxy groups in positions 4 and 7 on the benzofuran ring, a tertiary aminoethoxy side chain in position 6, and a N-methylurea group in position 5 led to the most active compounds.These were then tested orally in the Harris test in the dog.The two long-acting derivativesN--N'-methylurea (8j) and N--N'-methylurea (8m) showed advantages when compared to quinidine and diisopyramide and have been selected for further studies.